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Development and validation of machine learning models for predicting rehabilitation non-response after knee arthroplasty

Abstract: Structured rehabilitation after total knee arthroplasty (TKA) effectively improves health-related quality of life (HRQoL) and function, yet some patients fail to achieve…

Date: 2026-09-18

Timing matters: gastrostomy placement and outcomes in patients with head and neck cancer undergoing chemoradiotherapy

Abstract: Patients with head and neck cancer (HNC) undergoing chemoradiotherapy (CRT) are at high risk of malnutrition. The optimal timing of gastrostomy [percutaneous endoscopic…

Date: 2026-09-18

Improvement of residual dizziness associated with a low-dose vitamin D-calcium combination (Caltrate D) supplementation in female patients with benign paroxysmal positional vertigo after successful repositioning: an 8-week retrospective study

Abstract: Residual dizziness (RD) is a common and debilitating symptom following successful canalith repositioning procedure (CRP) for benign paroxysmal positional vertigo (BPPV).…

Date: 2026-09-18

Clinicopathological features and treatment paradigms exploration in advanced ampullary cancer

Abstract: Ampullary cancer presents unique clinical challenges due to its rarity and diagnostic complexities. Current data addressing ampullary cancer therapy are limited. This…

Date: 2026-09-18

Early time-of-day infusion of PD-1 inhibitor improves prognosis in advanced gastric cancer: a multicenter real-world study

Abstract: Whether the time-of-day administration (ToDA) of programmed cell death 1 (PD-1) inhibitor infusion influences survival in advanced gastric cancer (AGC) remains unclear.…

Date: 2026-09-18

Plasma multi-omics reveals molecular remodeling and prognostic biomarkers in advanced breast cancer treated with trastuzumab deruxtecan

Abstract: Trastuzumab deruxtecan (T-DXd), a HER2-targeted antibody-drug conjugate, has demonstrated clinical activity in HER2-positive and HER2-low advanced breast cancer.…

Date: 2026-09-18

Sleep disturbance, anxiety, and depression in postoperative ovarian cancer patients: prevalence, associated factors, and symptom interrelationships

Abstract: This study aimed to investigate the prevalence, associated factors, and interrelationships of sleep disturbance, anxiety, and depression in postoperative ovarian cancer…

Date: 2026-09-18

Targeting SYK enhances responses to radiotherapy and PD-1 blockade with myeloid immune remodeling in breast cancer

Abstract: Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase involved in immune signaling and has been implicated in tumor-intrinsic resistance to DNA-damaging…

Date: 2026-09-18

CAR T cell-induced interferon gamma enhances MHC class I expression and sensitizes neuroblastoma to TCR-engineered T cell therapy

Abstract: T cell receptor (TCR)-engineered T cells target antigens presented on major histocompatibility complex (MHC) class I molecules. MHC class I expression is often low in…

Date: 2026-09-18

Comparative associations of cumulative cholesterol-HDL-glucose index and triglyceride-glucose index with risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a prospective cohort study

Abstract: The American Heart Association recently introduced Cardiovascular-kidney-metabolic (CKM) syndrome as an integrated clinical construct. Evidence based on a single…

Date: 2026-09-18