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Efficacy, toxicity, and prognostic factors of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in elderly patients with diffuse large B-cell lymphoma: a single-center retrospective cohort study

Abstract: Optimizing treatment for elderly patients with diffuse large B-cell lymphoma (DLBCL) remains clinically challenging because curative intent must be balanced against…

Date: 2026-04-13

Comparison of time-segmented goal-directed teaching vs. traditional teaching for PICC among specialist nurse training: a randomized controlled trial

Abstract: This randomized controlled trial compared the efficacy of Time-Segmented Goal-Directed Teaching (TSGDT) vs. Traditional Teaching (TT) in enhancing Peripherally Inserted…

Date: 2026-04-13

Differential association of the 5-factor modified frailty index with postoperative pulmonary complications: specific prediction of infection risk after pulmonary lobectomy

Abstract: Frailty is recognized as an important predictor of postoperative outcomes, yet evidence on the differential association between the 5-factor modified frailty index…

Date: 2026-04-13

Association of the glucose metabolism continuum (fasting plasma glucose/HbA1c) with tear-film stability and secretion: ocular surface evidence across non-diabetes, prediabetes, and diabetes

Abstract: Whether gradations in glycemia across non-diabetes, prediabetes, and diabetes relate to tear?film homeostasis and dry eye disease (DED) remains uncertain, and…

Date: 2026-04-13

Unveiling the non-linear synergistic effects of smoking and aging on cataract-AMD comorbidity: an explainable artificial intelligence approach

Abstract: The comorbidity of cataract and age-related macular degeneration (AMD) poses a significant public health burden. Traditional linear statistical models often fail to…

Date: 2026-04-13

Preoperative information needs and preferences of refractive surgery patients: a discrete choice experiment

Abstract: Individualized preoperative information can enhance patient satisfaction. However, existing studies have methodological limitations, largely adopting a healthcare…

Date: 2026-04-13

Acute infection with the U.S. isolate of Theileria orientalis genotype Ikeda is associated with decreased hematocrit and erythrocyte counts in experimentally infected cattle

Abstract: The emergence of the tick-borne Ikeda genotype of Theileria orientalis poses a significant threat to the U.S. cattle industry. Although information has been gathered on…

Date: 2026-04-10

Long-term outcomes of co-administration of CD19 and CD22 CAR-T cell therapy in pediatric patients with relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia

Abstract: Despite initial responses, resistance to tyrosine kinase inhibitors (TKIs) and disease relapse remain major challenges in patients with Philadelphia chromosome-positive…

Date: 2026-04-10

Accelerated response and reduced chemotherapy with ruxolitinib-based regimen therapy in pediatric hemophagocytic lymphohistiocytosis: a retrospective comparison with HLH-94 regimen

Abstract: To compare the efficacy of a Ruxolitinib-based regimen versus the conventional HLH-94 protocol in children with newly diagnosed hemophagocytic lymphohistiocytosis (HLH).…

Date: 2026-03-26

Value, development challenges, and strategies for gaining internal endorsement of digitally connected subcutaneous drug delivery devices: a survey of pharmaceutical stakeholders

Abstract: Connected drug delivery devices such as combination products that integrate traditional drug delivery systems with digital connectivity features represent an opportunity…

Date: 2026-03-26