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Reversing chemoresistance in ovarian cancer: network pharmacology reveals how hydroxychloroquine/sulfasalazine duotherapy remodels tumor inflammatory–immune microenvironment

Abstract: Chemoresistance is a key contributor of ovarian cancer (OC) mortality. Clinical observations of extended survival in OC patients with rheumatic comorbidities following…

Date: 2026-03-26

Predictive value of uric acid and lactate dehydrogenase for maternal morbidity in preeclampsia: a retrospective case-control study

Abstract: Preeclampsia is a major cause of global maternal morbidity and mortality. This study aims to determine whether readily available and inexpensive biomarkers, serum uric…

Date: 2026-03-26

Sleep characteristics and cognitive impairment in bipolar disorder: age-specific associations

Abstract: Bipolar disorder (BD) is a chronic condition often associated with sleep disturbances and cognitive impairment, even during periods of clinical stability. This study…

Date: 2026-03-26

Latent profile analysis of compassion fatigue and its relationship with humanistic care ability among psychiatric nurses in Henan Province

Abstract: To explore the potential categories of compassion fatigue in psychiatric nurses and their relationship with humanistic care ability. From December 2024 to January 2025,…

Date: 2026-03-26

Refractive outcomes after cataract surgery in eyes with pterygium: validation of a regression-based keratometric prediction model

Abstract: This study aimed to validate a regression-based keratometric prediction model in eyes with pterygium using actual postoperative refractive outcomes after cataract…

Date: 2026-03-26

The effects of optic nerve sheath fenestration on visual function and OCT metrics in idiopathic intracranial hypertension: a retrospective study

Abstract: Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure (ICP) without an identifiable cause and may lead to optic nerve damage and…

Date: 2026-03-26

Systemic metabolic dysfunction is associated with local treatment failure: the role of visceral adiposity index in anti-VEGF resistance in diabetic macular edema

Abstract: A substantial number of patients with diabetic macular edema (DME) exhibit resistance to standard anti-vascular endothelial growth factor (anti-VEGF) therapy,…

Date: 2026-03-26

Three-dimensional progressive correction of Madelung deformity using the Ilizarov technique in patients aged ?12 years: a retrospective study

Abstract: Madelung deformity is a rare developmental wrist abnormality that often leads to joint pain and limited mobility. Traditional surgical methods typically struggle to…

Date: 2026-03-26

Integrated stress response genes as novel biomarkers and therapeutic targets in ankylosing spondylitis: a transcriptomic and Mendelian randomization study

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory disorder with poorly defined pathogenic mechanisms. The integrated stress response (ISR), an evolutionarily…

Date: 2026-03-26

Analysis of risk factors for relapse in pediatric MOG antibody-associated disease: a single-center retrospective cohort study

Abstract: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an immune-mediated demyelinating disorder of the central nervous system. It has a higher…

Date: 2026-03-26