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Development and validation of a machine learning model for predicting hypersplenism in Wilson disease patients

Abstract: Wilson disease (WD) is a rare autosomal recessive copper metabolism disorder, with hypersplenism as a severe, common complication secondary to disease-related cirrhosis.…

Date: 2026-03-18

Myasthenia gravis and anxiety-depression states: an integrated clinical and Mendelian randomization study

Abstract: Myasthenia gravis (MG) is an autoimmune disease affecting the postsynaptic membrane at the neuromuscular junction. Anxiety disorder and depression are common psychiatric…

Date: 2026-03-18

Isolated ventricular septal defect is not a risk factor for celiac disease: evidence from a large real-world data cohort of 493,382 children

Abstract: Ventricular septal defect (VSD) is one of the most common congenital heart defects in children. Celiac disease (CD) is known to cluster with autoimmune conditions and…

Date: 2026-03-18

A retrospective cohort study in China: association between Tripterygium glycosides and reduced serum albumin levels in elderly rheumatoid arthritis patients

Abstract: Tripterygium glycosides (TGs) are widely used in rheumatoid arthritis (RA) treatment, but their potential impact on serum proteins, particularly albumin, warrants…

Date: 2026-03-18

Epstein Barr virus antigen-induced autoantibodies against complement C1q exacerbate renal disease in lupus-prone mice

Abstract: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by the development of autoantibodies against multiple antigens, including complement…

Date: 2026-03-18

Intact lymph node homing and CD8 + T-cell priming abilities of Sprouty2-deficient dendritic cells

Abstract: Sprouty2 (Spry2) acts as a modulator of the MAPK-ERK signaling pathway by exerting both positive and negative regulation in a highly context- and cell type-specific…

Date: 2026-03-18

Immunoendocrine response to individual or combined exposure of polystyrene nanoplastics and elevated salinity on gilthead seabream

Abstract: The gilthead seabream ( Sparus aurata ) is one of the most important fish species in marine aquaculture, directly affected by different aspects of the “triple planetary…

Date: 2026-03-18

Cellular sensor DAP5 decodes Betacoronaviral NSP5 to drive virus-induced senescence

Abstract: Viral infection induces host cells to enter a state of “virus-induced senescence (VIS)”, which provides a stable cellular environment for viral replication. However, it…

Date: 2026-03-17

Neuron-specific expression of murine thyroid hormone transporters Mct8 and Oatp1c1 is dispensable for hippocampus-dependent neuronal functions

Abstract: Global absence of the thyroid hormone (TH) transporters monocarboxylate transporter 8 (Mct8) and organic anion transporting polypeptide 1c1 (Oatp1c1) in Mct8/Oatp1c1…

Date: 2026-03-17

Estimated small dense low-density lipoprotein cholesterol and hyperuricemia in diabetic patients

Abstract: Small dense low-density lipoprotein cholesterol (sdLDL-C) is a key driver of atherosclerotic cardiovascular disease risk. This study aims to investigate the relationship…

Date: 2026-03-17