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Primary cutaneous nocardiosis caused by Nocardia brasiliensis : isolation, susceptibility, and molecular identification in eight consecutive cases from a tertiary hospital

Abstract: Nocardiosis is caused by Gram-positive aerobic bacteria of the genus Nocardia , which are soil-dwelling saprophytes. Infection may also occur via direct inoculation,…

Date: 2026-03-09

FiO 2 requirements during general anesthesia with dual-lung ventilation: a prospective pilot study

Abstract: Hyperoxemia and prolonged oxygen exposure were common during general anesthesia. However, the relationship between FiO 2 and PaO 2 in patients undergoing general…

Date: 2026-03-09

S-ketamine plus dexmedetomidine vs. S-ketamine plus propofol for sedation–analgesia during positioning for spinal anesthesia in older adults undergoing lower extremity fracture surgery

Abstract: Positioning for neuraxial anesthesia in geriatric lower extremity fracture surgery is painful and can destabilize hemodynamics. Sedation–analgesia must balance effective…

Date: 2026-03-09

Prevalence and associated factors of thyroid nodules in a health examination cohort: an ultrasound-based cross-sectional study using electronic health records

Abstract: This large-scale cross-sectional study utilized electronic health records (EHRs) to determine the prevalence, sonographic characteristics, and independent correlates of…

Date: 2026-03-04

Machine learning-based prediction of PASI100 response to secukinumab in patients with psoriasis: a real-world study with SHAP interpretability analysis

Abstract: Secukinumab, an interleukin-17A (IL-17A) inhibitor, has demonstrated significant efficacy in treating moderate-to-severe plaque psoriasis. Achieving complete skin…

Date: 2026-02-27

AGR2 promotes tumor progression by regulating macrophage polarization via the CD98hc-xCT/p-ERK pathway

Abstract: Anterior gradient 2 (AGR2) contributes to tumorigenesis, yet its function within the tumor microenvironment (TME) and in macrophage polarization remains unclear. This…

Date: 2026-02-26

Beneficial effects of upadacitinib on a subgroup of patients with atopic dermatitis and hidradenitis suppurativa: a multicenter, real-world retrospective study

Abstract: Although AD and HS are significantly different clinically, they share common systemic comorbidities and some immunological pathways. The aim of this multicentric Italian…

Date: 2026-02-25

IgE-defined endotypes reveal distinct clinical profiles of prurigo nodularis compared with atopic dermatitis: a multicenter study in China

Abstract: Prurigo nodularis (PN) is a chronic inflammatory dermatosis that often coexists with atopic dermatitis (AD) but represents a distinct entity. Evidence directly comparing…

Date: 2026-02-25

Cross-tissue integrative transcriptomic and multimodal analyses suggest shared immune signatures linking lupus nephritis and cutaneous lupus erythematosus

Abstract: Lupus nephritis (LN) and cutaneous lupus erythematosus (CLE) are major organ manifestations of systemic lupus erythematosus (SLE), imposing significant health and…

Date: 2026-02-24

Could vector-derived cadherin mimicry contribute to pemphigus vulgaris? An immunogenetic and in silico study involving HLA-DRB104:02 and 14:01

Abstract: Pemphigus vulgaris (PV) is a potentially life-threatening autoimmune blistering disease characterized by autoantibodies directed against the desmosomal cadherins…

Date: 2026-02-18