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Age-dependent associations of peripheral inflammatory biomarkers with cognition and brain structural abnormalities in patients with Alzheimer’s disease and Alzheimer’s disease-related mild cognitive impairment

Abstract: Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative conditions. Chronic peripheral inflammation has been implicated in the pathophysiology of AD.…

Date: 2026-09-08

IFN-?–dominant immune shift is associated with reduced protective ILC2 responses in chronic kidney disease

Abstract: Chronic kidney disease (CKD) progression is driven by an imbalance between inflammatory injury and tissue repair; however, the immune mechanisms that disrupt reparative…

Date: 2026-09-08

The epidemiological landscape of canine tumors in central Italy: animal cancer registry insights, distribution patterns, and incidence estimates

Abstract: Animal cancer registries (ACRs) monitor companion animal tumors, providing essential data for comparative oncology. Sharing domestic environments and possessing…

Date: 2026-09-08

High prevalence of gonadal dysfunction in pediatric sarcoma survivors: insights from hormonal and clinical markers

Abstract: A critical proportion of childhood bone and soft tissue sarcoma survivors experience some form of reproductive impairment. These findings underscore the increasing need…

Date: 2026-09-07

Early-onset CLL is characterized by enhanced microenvironment-driven metabolic fitness, increased proliferative bias, and accelerated disease progression

Abstract: Chronic lymphocytic leukemia (CLL) predominantly affects older adults; however, approximately 10% of patients are diagnosed at a younger age. Although overall survival…

Date: 2026-09-07

Cognitive impairment as a mediator of treatment discontinuation after intracerebral hemorrhage in acute leukemia

Abstract: Neurological deficits after spontaneous intracerebral hemorrhage (ICH) are linked to treatment discontinuation in acute leukemia patients, but underlying mechanisms are…

Date: 2026-09-07

Associations of polymorphisms in the myeloid immunoregulatory receptor gene MRC1 with expression and prognosis in acute myeloid leukemia

Abstract: Acute myeloid leukemia (AML) shows substantial biological and clinical heterogeneity that extends beyond leukemia-intrinsic genetic alterations. MRC1, which encodes the…

Date: 2026-09-07

A machine-learning-derived online prediction model based on inflammatory and nutritional composite indicators for acute kidney injury in sepsis patients with multiple myeloma

Abstract: Acute kidney injury (AKI) frequently complicates sepsis in patients with multiple myeloma (MM), yet no validated predictive tool integrates the inflammatory and…

Date: 2026-09-07

Comparison of eight insulin-independent indices for identifying insulin resistance in Chinese young and middle-aged adults without diabetes: favorable performance of METS-IR and TyG-BMI

Abstract: Homeostasis model assessment of insulin resistance (HOMA-IR) mainly reflects basal IR, whereas dynamic measures such as the Matsuda index are less practical. This…

Date: 2026-09-07

Impaired bone health after pediatric acute lymphoblastic leukemia treatment despite normal DXA: insights from high-resolution peripheral quantitative computed tomography

Abstract: Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood. With improved survival rates, more attention has turned to long-term outcomes such as bone…

Date: 2026-09-07