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Dermatological adverse events in Chinese prostate cancer patients treated with the androgen receptor inhibitor apalutamide

Abstract: Background: Apalutamide, an androgen receptor inhibitor, has shown good efficacy in treating prostate cancer (PCa). However, dermatological adverse events (dAEs) are…

Date: 2025-02-20

Disease phenotypic and outcome of very-early onset inflammatory bowel disease in Asian children: an understudied population

Abstract: Background: There is a paucity of knowledge on disease phenotype and outcome of very early-onset (VEO) inflammatory bowel disease (VEO-IBD) from recently developed and…

Date: 2025-02-20

Understanding the link between ALDH2 genotypes and diabetes

Abstract: Introduction: The association between aldehyde dehydrogenase-2 (ALDH2) rs671 and diabetes remains controversial, with uncertainty about whether alcohol consumption or…

Date: 2025-02-19

Comparison of incidence trends of early-onset and late-onset type 2 diabetes in the Asia-Pacific region, 1990-2021: a join point regression analysis based on the global burden of disease study 2021

Abstract: Introduction: This study evaluated the incidence trends of early-onset (diagnosed at ages 15-39) and late-onset (diagnosed at age 40 and above) type 2 diabetes mellitus…

Date: 2025-02-19

Unveiling macrophage dynamics and efferocytosis-related targets in diabetic kidney disease: insights from single-cell and bulk RNA-sequencing

Abstract: Background: Chronic inflammation and immune imbalance mediated by macrophages are considered pivotal in diabetic kidney disease (DKD). The study aims to clarify the…

Date: 2025-02-19

The impact of allergic contact dermatitis on the inflammatory response and repair in wound healing process

Abstract: Background: Skin trauma and the subsequent wound healing process present significant challenges for healthcare systems and patients globally. Allergic contact dermatitis…

Date: 2025-02-19

Clinical application of Myxovirus resistance protein A as a diagnostic biomarker to differentiate viral and bacterial respiratory infections in pediatric patients

Abstract: Background: Differentiating between viral and bacterial respiratory tract infections in pediatric patients remains a significant diagnostic challenge, often leading to…

Date: 2025-02-19