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Machine-learning-based prediction model of type 2 diabetes using liver enzymes: a cross-sectional study

Abstract: Although observational studies have established associations between three major liver enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), and…

Date: 2026-09-03

Diabetes impairs antifungal immunity and drives fatal disseminated sporotrichosis in mice

Abstract: This study establishes and characterizes a novel experimental mouse model to evaluate Sporothrix brasiliensis infection under type 1 diabetic conditions, providing a…

Date: 2026-09-03

Progression of bilateral adrenal incidentalomas: a monocentric cohort study

Abstract: Bilateral adrenal incidentalomas (BAIs) are increasingly detected during abdominal imaging. Their initial clinical, hormonal, and radiological presentation is…

Date: 2026-09-03

SYTL5 drives malignant progression in differentiated thyroid carcinoma: unveiling its regulatory mechanisms

Abstract: To investigate the expression of SYTL5 in differentiated thyroid carcinoma (DTC) and elucidate its clinical significance and underlying molecular mechanisms. SYTL5…

Date: 2026-09-03

Disproportionate reporting of euglycaemic and diabetic ketoacidosis with SGLT-2 inhibitors across expanding cardiorenal indications: a cross-database study of FAERS and JADER

Abstract: SGLT-2 inhibitors are now used beyond type 2 diabetes (T2DM) in heart failure (HF) and chronic kidney disease (CKD), where glucose is monitored less routinely. Whether…

Date: 2026-09-03

Factors associated with poor cardiometabolic control in patients with type 2 diabetes: a Lasso-Firth penalized regression analysis

Abstract: To assess cardiometabolic control among patients with type 2 diabetes mellitus (T2DM) in Shanxi Province and identify variables associated with poor cardiometabolic…

Date: 2026-09-03

Efficacy and safety of semaglutide for obesity and hyperphagia in adults with Prader-Willi syndrome

Abstract: Prader-Willi syndrome is a genetic neurodevelopmental disorder characterized by hyperphagia and early-onset obesity from hypothalamic dysfunction with endocrinopathies…

Date: 2026-09-03

Long-term comorbidities and mortality associations with treatment in generalized pustular psoriasis: a multi-institutional cohort study

Abstract: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory disease with limited evidence on long-term prognosis and treatment–mortality associations. To compare…

Date: 2026-09-03

Differential risk signals of cutaneous adverse drug reactions among ?-lactam antibiotics: ceftriaxone shows increased signals for SJS/TEN in clinical and real-world cohorts

Abstract: Cutaneous adverse drug reactions (CADRs) are triggered by numerous antibiotic drugs. Most drug reactions are in the spectrum of a maculopapular eruption (MPE) with a…

Date: 2026-09-03

Clinical trial awareness and participation attitudes among patients with epidermolysis bullosa and their caregivers: a nationwide cross-sectional study from Saudi Arabia

Abstract: Epidermolysis bullosa (EB) is a rare, inherited skin fragility disorder with significant disease burden and rapidly evolving therapeutic options. Clinical trial…

Date: 2026-09-03