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Baseline and 72-h dynamic laboratory deficit burden for mortality through day 90 after acute ischemic stroke in critical care: landmark analyses with temporal validation

Abstract: A laboratory-based frailty index (FI-Lab) summarizes routinely measured deficits, but during critical illness it may reflect acute derangement and underlying…

Date: 2026-09-03

Predicting 6-month decisional regret among family surrogate decision-makers of ICU patients: development and internal validation of prediction models

Abstract: To develop and internally validate prediction models estimating the individual probability of high decisional regret at 6?months among family surrogate decision-makers…

Date: 2026-09-03

Design, implementation, and evaluation of a programmatic assessment model in an emergency medicine residency: a mixed-methods study

Abstract: Programmatic assessment (PA) is widely endorsed in postgraduate medical education, but empirical accounts of real-world implementation in emergency medicine (EM) remain…

Date: 2026-09-03

Development and validation of an explainable machine learning model for differentiating diabetic nephropathy from diabetic retinopathy in patients with type 2 diabetes

Abstract: Diabetic nephropathy (DN) and diabetic retinopathy (DR) are common microvascular complications of type 2 diabetes mellitus (T2DM) and may require different diagnostic…

Date: 2026-09-03

Construction and validation of a nomogram model for predicting 60-day mortality in patients with acute myeloid leukaemia

Abstract: To construct and internally validate a nomogram for predicting 60-day all-cause mortality in adult patients with de novo acute myeloid leukaemia (AML) and to compare its…

Date: 2026-09-03

Motivational and emotional determinants of health goal progress in inflammatory bowel disease: a longitudinal study

Abstract: Self-management among patients with inflammatory bowel disease (IBD) is influenced by motivational and emotional factors. Although research has increasingly highlighted…

Date: 2026-09-03

Development and validation of a nomogram prediction model for perioperative delirium in older patients with osteoporotic fractures based on LASSO regression and multiple parameters

Abstract: Perioperative delirium (POD) is a severe postoperative complication in older patients with osteoporotic fractures. This study aimed to establish a nomogram prediction…

Date: 2026-09-03

Targeting bromodomain and extra-terminal proteins reprograms macrophages and inhibits breast cancer progression

Abstract: Breast cancer (BC) remains a leading cause of cancer-related deaths, with resistance to therapy driving tumor progression. While immune checkpoint inhibitor (ICI)…

Date: 2026-09-03

Personal sense of coherence and posttraumatic stress symptoms among internally displaced women exposed to the Anglophone Crisis in Cameroon

Abstract: Women and girls affected by armed conflict and forced displacement are exposed to a high burden of potentially traumatic events, gendered insecurity, disrupted social…

Date: 2026-09-03

Prevalence of financial toxicity and construction of a risk prediction model for lung cancer patients at 6 months after discharge

Abstract: To investigate the prevalence of 6-month post-discharge financial toxicity in lung cancer patients, identify its independent predictors, and establish a valid risk…

Date: 2026-09-03