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Clinical phenotypes, endotypes, and biomarker profiles of immediate rituximab hypersensitivity reactions: a prospective pharmacovigilance study

Abstract: Rituximab (RTX) has been associated with immediate hypersensitivity reactions (HSRs) involving multiple phenotypes and endotypes. To characterize the clinical phenotypes…

Date: 2026-09-03

Prenatal maternal infection promotes maternal microchimeric cells to alter infection risk in male offspring

Abstract: Vertically transferred maternal cells or maternal microchimeric cells (MMCs) engraft the fetus and persist in offspring for long periods of time. How altered maternal…

Date: 2026-09-03

The effectiveness of the intervention model based on cognitive behavioral therapy in reducing risky sexual behaviors among MSM

Abstract: Based on CBT theory and the Internet, we established an intervention model targeting high-risk sexual behavior patterns in MSM. We then conducted a randomized controlled…

Date: 2026-09-03

Minocycline ameliorates CNS autoimmunity through restraint of CD4 + CD11bc + cells

Abstract: Minocycline is a tetracycline antibiotic with profound anti-inflammatory activity directed primarily against microglial cells and macrophages. Activation of nuclear…

Date: 2026-09-03

Complete blood count-derived myeloid-lymphoid inflammatory phenotype in rheumatoid arthritis complicated by acute myocardial infarction: an age- and sex-balanced retrospective study

Abstract: Rheumatoid arthritis (RA) is associated with excess cardiovascular morbidity, including acute myocardial infarction (AMI). Routine complete blood count (CBC)-derived…

Date: 2026-09-03

Tonsillar Tfh cells contribute to the pathogenesis of IgA nephropathy in collaboration with memory B cells

Abstract: Immunoglobulin A nephropathy (IgAN) is a chronic glomerular disease characterized by mesangial IgA deposition, which can progress to end-stage renal failure.…

Date: 2026-09-03

Development and external validation of a clinical-genetic risk identification model for rheumatoid arthritis-associated interstitial lung disease

Abstract: This study aimed to develop and externally validate a clinical risk identification model for prevalent rheumatoid arthritis-associated interstitial lung disease (RA-ILD)…

Date: 2026-09-03

Beyond the snapshot: continuous optical surface monitoring reveals non-linear temporal dynamics and postural stability window in free-breathing breast radiotherapy

Abstract: This study aimed to evaluate the clinical consistency between AlignRT surface monitoring and fan-beam computed tomography (FBCT)–based single-timepoint volumetric…

Date: 2026-09-03

Perioperative CALLY dynamics after curative gastrectomy for gastric adenocarcinoma: associations with nodal tumor burden, textbook surgical outcome, and disease-free survival

Abstract: The C-reactive protein–albumin–lymphocyte index (CALLY) integrates inflammation, nutrition, and cellular immunity. Its relationships with nodal tumor burden and…

Date: 2026-09-03

An investigational prognostic framework for stage IVB cervical cancer based on metastatic patterns: a population-based study with exploratory external evaluation

Abstract: Current staging system classifies all patients with metastatic cervical cancer as stage IVB, without accounting for prognostic heterogeneity. This study aimed to develop…

Date: 2026-09-03