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Integrated analysis of the relationship between metabolic pathways and immune infiltration in rheumatoid arthritis

Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovitis and systemic inflammation. Growing evidence highlights the critical role…

Date: 2025-12-12

Central venous catheter care and the healthcare–environment interface: outcomes of a quality improvement initiative in a resource-constrained ICU

Abstract: Central line-associated bloodstream infections (CLABSI) are major indicators of healthcare quality and patient safety, particularly in resource-constrained intensive…

Date: 2025-12-12

Low complement items play different roles on the classification performance of SLICC-2012, EULAR/ACR-2019, and SLERPI

Abstract: This study aimed to explore the association of low complement items with the performance of the systemic lupus erythematosus (SLE) classification criteria. This study…

Date: 2025-12-12

RUNX1-FPDMM in families with mild thrombocytopenia and platelet function anomalies: a case series

Abstract: RUNX1-familial platelet disorder with associated myeloid malignancy (RUNX1-FPDMM) is caused by heterozygous germline variants of RUNX1 . With the broader application of…

Date: 2025-12-11

Effects of short-term very low-calorie diet on metabolic profile in patients with metabolic syndrome

Abstract: Accumulating evidence indicates that dietary modifications confer beneficial effects on metabolic syndrome (MetS). In clinical practice, short-term very low-calorie…

Date: 2025-12-11

Fasting glucagon as an independent risk indicator for CAD in patient with type 2 diabetes

Abstract: To investigate the association between fasting glucagon levels and coronary artery disease (CAD) risk in patients with Type 2 Diabetes Mellitus (T2DM). This…

Date: 2025-12-11

Development and validation of a risk prediction model for multidrug-resistant organisms infection in diabetic foot ulcer patients

Abstract: To develop and validate a nomogram for predicting the risk of multidrug-resistant organisms (MDROs) infection in diabetic foot ulcer (DFU) patients. 701 DFU patients…

Date: 2025-12-11

Analysis of intestinal microorganisms and metabolite in childhood allergic asthma: role in assessing the severity of condition in children

Abstract: Childhood allergic asthma is a widespread chronic respiratory condition that is becoming more common worldwide. Presently, the evaluation of its severity depends on…

Date: 2025-12-11

Identification of novel variants underlying non-syndromic primary ovarian insufficiency using a targeted NGS gene panel

Abstract: Primary ovarian insufficiency (POI) affects 1-4% of women and is associated with infertility and reduced life expectancy. Most cases are idiopathic, and a genetic…

Date: 2025-12-11

The role of macrophages in the mitigation by decitabine of acute allograft rejection

Abstract: We have recently shown that the DNA hypomethylating agent decitabine (DAC) rescues lung allografts from acute rejection. This involves a mechanism that is dependent on…

Date: 2025-12-11