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Etiology and clinical characteristics of infantile cholestasis: a single-center retrospective study of 326 cases

Abstract: To retrospectively investigate the clinical characteristics and etiological spectrum of infantile cholestasis, with an emphasis on evolving diagnostic approaches.…

Date: 2026-04-22

Association of endoscopic intervention with mortality in gastrointestinal bleeding after open-heart surgery: a propensity-score cohort study

Abstract: Postoperative gastrointestinal bleeding (GIB) after open-heart surgery is associated with increased mortality, yet the prognostic impact of endoscopic intervention…

Date: 2026-04-22

Deciphering the macrophage ferroptosis regulatory network: construction of an ulcerative colitis diagnostic model and investigation of the immune microenvironment based on single-cell and transcriptomic data

Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease manifested as persistent mucosal inflammation and immune dysregulation. As key regulators of intestinal…

Date: 2026-04-22

Plasma soluble cellular prion protein reflects ischemic stroke severity and is associated with circulating CD4 + T cell immune responses

Abstract: The soluble form of cellular prion protein (PrP C ) in plasma has been investigated as a biomarker in multiple conditions, yet its relationship with ischemic stroke…

Date: 2026-04-22

Optimal timing of endovascular treatment for symptomatic intracranial atherosclerotic stenosis: a real world single center study

Abstract: To determine the optimal timing of endovascular treatment for acute cerebral infarction with symptomatic intracranial atherosclerotic stenosis (sICAS) in real world…

Date: 2026-04-22

Sleep quality metrics combined with virtual reality motion parameters enhance early detection of mild cognitive impairment

Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by cognitive and motor deficits. With its global prevalence increasing rapidly and no…

Date: 2026-04-22

Continuous antiretroviral therapy induces progressive senescence-like reprogramming of alveolar macrophages

Abstract: Advances in antiretroviral therapy (ART) have substantially improved the lives of people with HIV (PWH) and reduced HIV acquisition through pre-exposure prophylaxis…

Date: 2026-04-22

Clinical description, genetic analysis and characterization of two NLRP12 heterozygous VUS variants

Abstract: Systemic autoinflammatory diseases (SAIDs) are a rare, heterogeneous group of disorders caused by dysregulated innate immune activation. To characterize the phenotype…

Date: 2026-04-22

Intravitreal AAV vector delivery induces integrin-dependent ocular inflammation, complement activation, and antiviral and DNA damage responses

Abstract: Intravitreal delivery of adeno-associated virus (AAV) vectors offers a promising, minimally invasive strategy for retinal gene therapy, but remains limited by…

Date: 2026-04-22

Clinical, immunological, treatment characteristics, and outcomes in 22 patients with major histocompatibility complex class II deficiency

Abstract: Major histocompatibility complex (MHC) class II deficiency is a rare, life-threatening primary immunodeficiency that presents in early infancy with a SCID phenotype.…

Date: 2026-04-22