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Clinical efficacy of the laparoscopic modified Soave procedure for Hirschsprung's disease: a comparative retrospective cohort study

Abstract: Hirschsprung's disease (HSCR) is the second most common congenital gastrointestinal malformation, posing a significant health concern in pediatrics. The laparoscopic…

Date: 2025-12-19

Predicting infectious etiology and severity in hospitalized pediatric pneumonia using blood cytokine biomarkers

Abstract: Lower respiratory infections are a significant cause of morbidity and mortality in children. The aim of this study was to determine whether cytokine levels measured in…

Date: 2025-12-19

Association between preoperative anxiety and ciprofol requirements in women undergoing surgical abortion: a prospective observational study

Abstract: To investigate the association between preoperative anxiety level and ciprofol consumption in patients undergoing surgical abortion. A total of 144 patients scheduled…

Date: 2025-12-19

Radiomic approach to support multidisciplinary tumor board decision-making in locally advanced non-small cell lung cancer

Abstract: Selecting the optimal treatment for locally advanced non-small cell lung cancer (LA-NSCLC) is complex and typically requires multidisciplinary tumor board (MTB)…

Date: 2025-12-19

Vonoprazan-related adverse events: a pharmacovigilance study based on the FDA adverse event reporting system

Abstract: This study comprehensively evaluated the safety profile of Vonoprazan using data from the FDA Adverse Event Reporting System (FAERS) from the first quarter (Q1) of 2023…

Date: 2025-12-19

Dietary vitamin B9 intake linked to drug-resistant epilepsy risk in western Chinese adults: exploring underlying metabolomic mechanisms

Abstract: Approximately 30% of epilepsy patients develop drug-resistant epilepsy (DRE), underscoring the need for adjunctive therapies. While dietary interventions like the…

Date: 2025-12-19

Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages

Abstract: PANoptosis is a form of inflammatory cell death that exhibits simultaneous activation of pyroptosis, apoptosis and necroptosis signaling. Disulfiram is a clinically used…

Date: 2025-12-19

Plasma cell-free DNA genome-wide methylation profiling enables detection and activity assessment in systemic lupus erythematosus

Abstract: Cell-free DNA (cfDNA) has emerged as a promising non-invasive biomarker in precision medicine and is increasingly recognized as relevant to relevance in systemic lupus…

Date: 2025-12-19

Impact of inotuzumab ozogamicin as bridging therapy and tumor burden in CAR-T therapy for B-acute lymphoblastic leukemia

Abstract: Inotuzumab ozogamicin is increasingly being used as bridging therapy (BT) prior to chimeric antigen receptor T-cell (CAR-T) in relapsed/refractory B-cell acute…

Date: 2025-12-18

Pediatric acute lymphoblastic leukemia relapse and prognosis: key predictors and therapeutic implications

Abstract: Pediatric acute lymphoblastic leukemia (ALL), the most common childhood malignancy, achieves >95% 5-year survival with risk-adapted therapies. Nonetheless, 10%–15% of…

Date: 2025-12-18