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Hyperopic reserve insufficiency and myopic pre-disposition in pre-school children aged 3–6 years: a large-scale cross-sectional survey

Abstract: To estimate the prevalence of hyperopic reserve insufficiency (HRI) and examine its associated factors among pre-school children aged 3–6 years in Ganzhou, China. This…

Date: 2026-08-10

Targeted plasma lipidomics in non-metastatic colorectal cancer, metastatic colorectal cancer, and healthy controls: an exploratory matched-triplet study

Abstract: Systemic lipid remodeling accompanies colorectal cancer (CRC), but whether circulating lipid alterations specifically distinguish metastatic from non-metastatic disease…

Date: 2026-08-10

Quantitative HBsAg as a biomarker for disease staging in untreated chronic hepatitis B patients: a cross-sectional study

Abstract: Chronic hepatitis B virus (HBV) infection is a major issue in North Africa, where HBeAg-negative profiles are predominant. Distinguishing between chronic infection and…

Date: 2026-08-10

IL27 expression and IL27RA-dependent cellular responses are associated with biochemical recurrence and immune-regulatory features in prostate cancer

Abstract: Biochemical recurrence remains a clinically heterogeneous event in prostate cancer, yet the immune signals associated with relapse-prone tumors are not fully defined.…

Date: 2026-08-10

From disease-specific control to system-embedded governance: a multidimensional policy design analysis of stroke prevention and stroke center development in China

Abstract: Stroke remains a major cause of death, disability, and long-term care burden in China. National policy has expanded from disease-specific prevention and treatment to…

Date: 2026-08-10

Carotid napkin-ring sign plaques are associated with early neurological deterioration in lenticulostriate artery branch atheromatous disease

Abstract: Early neurological deterioration (END) is a frequent and devastating clinical feature of branch atheromatous disease (BAD). The napkin-ring sign (NRS) on computed…

Date: 2026-08-10

Serum IL-6 and functional outcome after endovascular therapy: the mediating role of infarct volume growth in acute ischemic stroke

Abstract: Inflammatory factors are pivotal in systemic and central nervous system inflammation post-stroke. This study examined if peripheral inflammatory factors were associated…

Date: 2026-08-10

Electrophysiological readout of ACTH-related neuroendocrine–immunomodulatory treatment response in infantile epileptic spasms syndrome: suppression of scalp ripple propagation networks

Abstract: Adrenocorticotropic hormone (ACTH) is a first-line neuroendocrine–immunomodulatory therapy for infantile epileptic spasms syndrome (IESS), but noninvasive…

Date: 2026-08-10

CXCR6 + natural killer cell immunotherapy preserves CD4 + T helper cells in humanized mice

Abstract: Human immunodeficiency virus (HIV) persists despite antiretroviral therapy because long-lived viral reservoirs are not eliminated, and ongoing or rebound infection…

Date: 2026-08-10

Associations of hereditary angioedema attacks with intestinal permeability and inflammatory cytokines

Abstract: Hereditary angioedema (HAE) is characterized by recurrent subcutaneous and submucosal edema. Gastrointestinal involvement is common; however, the role of intestinal…

Date: 2026-08-10