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A genetically determined molecular switch modulates the anti-inflammatory potential of human IgA

Abstract: Fc receptor-driven immune system activity typically reflects a balance of activating and inhibitory mechanisms, mediated by the immunoreceptor tyrosine-based activation…

Date: 2025-08-27

Functional characterization and clinical significance of IGSF8 in pan-cancer: an integrated bioinformatic and experimental study

Abstract: Immunoglobulin superfamily member 8 (IGSF8) is a membrane protein implicated in crucial biological processes like cell interactions and immune responses. Emerging…

Date: 2025-08-27

CS Ratio is an immune-related prognostic biomarker for cervical cancer

Abstract: The tumor microenvironment (TME) plays a crucial role in cancer progression but its complex structure significant variability among patients present considerable…

Date: 2025-08-27

Multi-omics modality completion and knowledge distillation for drug response prediction in cervical cancer

Abstract: In clinical practice, the development of personalized treatment strategies for cervical cancer is hindered by the limited accuracy of drug response prediction, partly…

Date: 2025-08-27

Tubular epithelial cell-derived extracellular vesicles carrying serum amyloid A1 exacerbate sepsis-associated acute kidney injury by promoting NETs formation

Abstract: Sepsis-associated acute kidney injury (SA-AKI) is a highly lethal condition with a rapid onset, and effective treatments are lacking because the molecular pathogenesis…

Date: 2025-08-27

Shared immune-inflammatory mechanisms between ulcerative colitis and periodontitis: a multi-omics analysis

Abstract: Ulcerative colitis (UC) and periodontitis (PD) are chronic inflammatory diseases with increasing evidence of bidirectional communication through the oral–gut axis.…

Date: 2025-08-27

Evaluating the triglyceride-glucose index as a biomarker for inflammatory bowel disease risk: insights from a UK Biobank prospective study

Abstract: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic inflammatory condition with rising global incidence. This…

Date: 2025-08-27

Early-life undernutrition, immune dysregulation, and cancer incidence in later life: a national life-course analysis from the China health and retirement longitudinal study

Abstract: Severe childhood famine may imprint durable immunometabolic scars, yet its longitudinal impact on chronic inflammation and cancer trajectories in China’s ageing…

Date: 2025-08-27

Trispecific eFab-eIg T-cell engagers targeting HER2 and HER3

Abstract: Trispecific antibodies have emerged as molecules for enhanced cancer immunotherapy by addressing the complexity of cancer cell biology and anti-cancer immune responses.…

Date: 2025-08-27

Correlation between serum ANCA and cancer: a decade-long retrospective analysis of an Italian cohort

Abstract: Serum antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies primarily linked with ANCA-associated vasculitides (AAV) but associated diseases include also other…

Date: 2025-08-27