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SGLT2 inhibition, uric acid and inflammation in glycemic burden-related progression of cardiac autonomic neuropathy in type 2 diabetes mellitus: insights from machine learning and mediation analysis

Abstract: To identify independent predictors of diabetic cardiac autonomic neuropathy (DCAN) deterioration in patients with type 2 diabetes mellitus (T2DM), develop machine…

Date: 2026-08-05

Behavioral and health-factor domains of Life’s Essential 8 in advanced cardiovascular-kidney-metabolic syndrome among Korean adults: a nationally representative cross-sectional analysis

Abstract: Life’s Essential 8 (LE8) summarizes cardiovascular health through four behavioral and four health-factor metrics, whereas cardiovascular-kidney-metabolic (CKM) syndrome…

Date: 2026-08-05

Systemic energy metabolism changes in patients with heart failure receiving specific oral nutritional supplements in combination with Mediterranean diet

Abstract: Heart failure (HF) is associated with disease-related malnutrition, all of which contribute to impaired functional capacity and adverse outcomes. Nutritional strategies…

Date: 2026-08-05

Time-resolved multi-omics reveals macrophage-centered immunometabolic remodeling in cutaneous dematiaceous fungal infection

Abstract: Dematiaceous fungi cause chronic, invasive cutaneous infections that are difficult to eradicate and frequently relapse despite antifungal therapy. Although host immunity…

Date: 2026-08-05

Epithelial skin cancer before, during, and after the COVID-19 pandemic

Abstract: The COVID-19 pandemic caused significant changes in healthcare, but its effects on patients with severe skin diseases are not yet fully understood. To assess the impact…

Date: 2026-08-05

Alternative diagnoses in neonates undergoing therapeutic hypothermia for presumed hypoxic–ischemic encephalopathy

Abstract: Early identification of hypoxic–ischemic encephalopathy (HIE) remains challenging during the first hours of life, and therapeutic hypothermia (TH) is often initiated…

Date: 2026-08-05

Three phosphatidylcholines as a potential early-diagnostic signature for hyperglycemia in preschool-aged children: a cross-sectional pilot study

Abstract: Although lipid metabolism dysregulation commonly accompanies elevated blood glucose, lipidomic studies in hyperglycemic children remain limited. We hypothesized that…

Date: 2026-08-05

Same child, different risk: demographic bias in childhood obesity attribution by large language models

Abstract: Large language models (LLMs) are increasingly consulted for pediatric health information, yet their demographic biases remain unsystematically evaluated in pediatric…

Date: 2026-08-05

Impact of early corticosteroid therapy on short-term pulmonary function and clinical outcomes in children with severe Mycoplasma pneumoniae pneumonia

Abstract: Severe Mycoplasma pneumoniae pneumonia (SMPP) in children can lead to pulmonary function impairment. This study aimed to evaluate the impact of early corticosteroid…

Date: 2026-08-05

Serum IL-32? as a biomarker for remission assessment in systemic lupus erythematosus

Abstract: To investigate the potential of serum interleukin (IL)-32? levels as a biomarker for assessing lupus low disease activity state (LLDAS) and remission, the targets of a…

Date: 2026-08-05