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Impact of multifocal soft contact lenses on the shape discrimination threshold under glare in myopic children

Abstract: Multifocal soft contact lenses (MFSCLs) are widely used to control myopia progression in children. However, their optical design may affect visual quality, especially…

Date: 2025-08-29

Molecular mechanisms of ferroptosis in ulcerative colitis: insights from machine learning, WGCNA, and immune cell infiltration analysis

Abstract: This study aimed to investigate ferroptosis-related biomarkers and their potential molecular basis in UC. UC datasets (GSE87466 and GSE47908) from the Gene Expression…

Date: 2025-08-29

Quantifying aerosol and microbial exposure of healthcare workers in endoscopy suites: a time-based study

Abstract: This study aimed to quantify aerosol and microbial exposure levels during different working hours, analyze temporal air pollution trends in the endoscopy suite, and…

Date: 2025-08-29

Hypocomplementemia dynamics during tocilizumab therapy in systemic juvenile idiopathic arthritis: a retrospective longitudinal study

Abstract: This study aimed to investigate the trajectory of complement C3 and C4 levels during tocilizumab (TCZ) treatment in patients with systemic juvenile idiopathic arthritis…

Date: 2025-08-29

Global, regional, and national burden of early-onset ischemic heart disease: trends and projections among adults aged 15–44 years from 1990 to 2046

Abstract: Ischemic heart disease (IHD) among young adults represents an emerging global health concern, yet comprehensive epidemiological assessments remain limited. This study…

Date: 2025-08-29

IgT and IgD dominance in the teleost central nervous system

Abstract: Although initially described as an immune-privileged site, the central nervous system (CNS) is now known to harbor a resident immune system, composed of different innate…

Date: 2025-08-29

c-Met inhibitor NVP-BVU972 induces antiviral protection and suppresses NF-?B-mediated inflammation

Abstract: Inhibiting viral replication and limiting NF-?B-driven inflammation simultaneously is essential for better antiviral therapy, highlighting the urgent need for a single…

Date: 2025-08-29

Bone marrow-derived extracellular vesicles from multiple myeloma patients promote adaptive immune dysfunction via HLA-G, PD-1, and PD-L1

Abstract: Extracellular vesicles (EVs) are critical mediators of intercellular communication and contribute to cancer progression and immune regulation. We characterized EVs…

Date: 2025-08-28

African regional and national burden of diabetes mellitus and its attributable risk factors from 1990 to 2021: results from the global burden of disease study 2021

Abstract: Diabetes mellitus (DM), a chronic disease characterized by hyperglycemia, has become a global health concern. This study evaluates the burden of DM in the African region…

Date: 2025-08-28

Serum proteomics analysis of lung transplant patients receiving different induction therapies

Abstract: Induction therapy is widely used in lung transplantation to control the host alloresponse, reducing acute cellular rejection and improving graft survival. Despite its…

Date: 2025-08-28