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Modular engineered outer membrane vesicles for synergistic cancer immunotherapy via PD-L1 blockade and epigenetic reprogramming

Abstract: Immune checkpoint inhibitors have significantly improved therapeutic outcomes in advanced melanoma; however, their clinical efficacy is greatly limited by low overall…

Date: 2026-07-31

CXCL1-CXCR2 axis inhibits melanogenesis through the suppression of the WNT/?-catenin pathway

Abstract: Abnormal skin pigmentation is a common clinical dermatological issue, and its occurrence and development are closely associated with the inflammatory microenvironment.…

Date: 2026-07-31

Body mass index, lung function, and FeNO in children with positive bronchodilator response: a cross-sectional study

Abstract: To investigate the association between body mass index (BMI) and pulmonary function in pediatric outpatients with positive bronchodilator response. We hypothesized that…

Date: 2026-07-31

Social media exposure and its association with acceptance of cosmetic surgery among adult females in Jazan

Abstract: Social media exposure may be associated with women's attitudes toward cosmetic surgery, yet data from Saudi Arabia's Jazan region are lacking. To evaluate acceptance of…

Date: 2026-07-31

Time-dependent immune and skeletal alterations following total-body irradiation and hematopoietic stem cell transplantation in a murine arthritis model

Abstract: Hematopoietic stem cell transplantation (HSCT) after cytotoxic conditioning, such as total-body irradiation (TBI), is widely used to treat hematologic and immune…

Date: 2026-07-31

Identity under threat: internal conflict and stigma in undetected child sexual abuse material users

Abstract: Individuals who use child sexual abuse material (CSAM) represent an under-researched population, particularly those who remain undetected by the legal system and outside…

Date: 2026-07-31

Internal validation of a residual thyroid recurrence model after PTC

Abstract: At present, the risk factors contributing to the recurrence of papillary thyroid carcinoma (PTC) in residual thyroid tissue post-surgery are not yet fully understood.…

Date: 2026-07-31

Initial conceptual development of a pilot questionnaire for patient-perceived clinical inertia in chronic disease management: an exploratory study with a predominantly Peruvian sample

Abstract: Clinical inertia has traditionally been conceptualized as a physician-centred phenomenon; however, in chronic disease management, it may also be influenced by…

Date: 2026-07-31

In-hospital inflammatory-nutritional-renal trajectory phenotypes and 90-day readmission or mortality in patients with acute decompensated heart failure: a retrospective cohort study

Abstract: Patients hospitalized with acute decompensated heart failure (ADHF) remain at high risk for early readmission and death after discharge. Static biomarkers may not fully…

Date: 2026-07-31

Development and validation of a nomogram for early nutritional risk stratification in elderly patients with pulmonary sepsis: a retrospective cohort study

Abstract: Malnutrition is highly prevalent among elderly patients with sepsis and is associated with adverse outcomes; however, early identification of nutritional risk remains…

Date: 2026-07-31