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AMPK-OXSR1 signaling coordinates proximal tubular sodium transport and is modulated by canagliflozin

Abstract: The with-no-lysine kinase (WNK)/oxidative stress-responsive kinase 1 (OXSR1) pathway is vital for renal sodium transport in the distal nephrons as it regulates chloride…

Date: 2026-07-31

Thyroid hormone sensitivity, insulin resistance and visceral fat area as determinants of prevalent coronary heart disease in euthyroid patients with type 2 diabetes

Abstract: Coronary heart disease (CHD) remains a leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Whether thyroid hormone sensitivity…

Date: 2026-07-31

Association of hepatic steatosis with MRI-defined renal steatosis in type 2 diabetes: a cross-sectional imaging and clinical modeling study

Abstract: Fatty Kidney Disease (FKD) is increasingly recognized as a distinct clinical entity, often coexisting with metabolic dysfunction-associated fatty liver disease (MAFLD)…

Date: 2026-07-31

Qing-Re-Qu-Shi formula improves clinical outcomes and is accompanied by gut microbiota and microbial metabolite remodeling in adults with moderate atopic dermatitis: a randomized placebo-controlled multi-omics trial

Abstract: The gut–skin axis is increasingly implicated in atopic dermatitis (AD), but randomized adult studies linking clinical response to paired gut microbiome and circulating…

Date: 2026-07-31

Trajectory-based profiling of 52-week secukinumab response reveals baseline clinical and transcriptomic differences in plaque psoriasis

Abstract: Response to secukinumab in psoriasis varies over time and is not fully captured by single timepoint endpoints. Baseline features associated with long-term response…

Date: 2026-07-31

Modular engineered outer membrane vesicles for synergistic cancer immunotherapy via PD-L1 blockade and epigenetic reprogramming

Abstract: Immune checkpoint inhibitors have significantly improved therapeutic outcomes in advanced melanoma; however, their clinical efficacy is greatly limited by low overall…

Date: 2026-07-31

CXCL1-CXCR2 axis inhibits melanogenesis through the suppression of the WNT/?-catenin pathway

Abstract: Abnormal skin pigmentation is a common clinical dermatological issue, and its occurrence and development are closely associated with the inflammatory microenvironment.…

Date: 2026-07-31

Body mass index, lung function, and FeNO in children with positive bronchodilator response: a cross-sectional study

Abstract: To investigate the association between body mass index (BMI) and pulmonary function in pediatric outpatients with positive bronchodilator response. We hypothesized that…

Date: 2026-07-31

Social media exposure and its association with acceptance of cosmetic surgery among adult females in Jazan

Abstract: Social media exposure may be associated with women's attitudes toward cosmetic surgery, yet data from Saudi Arabia's Jazan region are lacking. To evaluate acceptance of…

Date: 2026-07-31

Time-dependent immune and skeletal alterations following total-body irradiation and hematopoietic stem cell transplantation in a murine arthritis model

Abstract: Hematopoietic stem cell transplantation (HSCT) after cytotoxic conditioning, such as total-body irradiation (TBI), is widely used to treat hematologic and immune…

Date: 2026-07-31