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Trispecific eFab-eIg T-cell engagers targeting HER2 and HER3

Abstract: Trispecific antibodies have emerged as molecules for enhanced cancer immunotherapy by addressing the complexity of cancer cell biology and anti-cancer immune responses.…

Date: 2025-08-27

Correlation between serum ANCA and cancer: a decade-long retrospective analysis of an Italian cohort

Abstract: Serum antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies primarily linked with ANCA-associated vasculitides (AAV) but associated diseases include also other…

Date: 2025-08-27

ISG15 mRNA transcript level in circulating leucocytes prognostic of overall survival in hepatocellular carcinoma patients and correlated with quality of life disturbances involved in anorexia-cachexia

Abstract: An increasing number of immuno-therapeutic agents have proven efficacy in hepatocellular carcinoma (HCC). Inflammatory markers (c-reactive protein, interleukin-8 and…

Date: 2025-08-27

Neoadjuvant immunotherapy plus chemotherapy for resectable non-small cell lung cancer with driver mutations: a retrospective analysis

Abstract: Neoadjuvant immunotherapy combined with chemotherapy offers significant benefits for patients with resectable non-small cell lung cancer (NSCLC). However, its efficacy…

Date: 2025-08-27

Emerging causes of anticancer therapies?induced Stevens-Johnson syndrome and toxic epidermal necrolysis: evidence from disproportionality analysis of the FDA adverse event reporting system

Abstract: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are potentially fatal cutaneous adverse events of drug treatment. Evidence for SJS/TEN risk from…

Date: 2025-08-27

Isolated hypoxic pelvic perfusion combined with electroporation is a valid alternative to traditional therapies for anal squamous cell carcinoma: a case study

Abstract: We report a series of four patients with HPV-positive squamous cell carcinoma of the anus: two with non-previously treated grade G3 malignancies, and two with relapsing…

Date: 2025-08-27

Targeted and personalized immunotherapy in lung adenocarcinoma: single-cell RNA sequencing of MAFF + tumor cells and the therapeutic potential of FOS

Abstract: Non-small cell lung cancer (NSCLC) was a major cause of cancer-related mortality globally. Despite advancements in immunotherapy and targeted therapies, clinical…

Date: 2025-08-27

Integration of single-cell and bulk RNA sequencing to identify unique tumor stem cells and construct novel prognostic markers for assessing ESCA prognosis and drug sensitivity

Abstract: Cancer stem cells (CSCs) are crucial contributors to the development and progression of esophageal cancer (ESCA). This study utilized single-cell RNA sequencing…

Date: 2025-08-27

Real-world cardiovascular risks of ibrutinib in chronic lymphocytic leukemia: a retrospective study

Abstract: Ibrutinib has made significant contributions to the treatment of chronic lymphocytic leukemia (CLL) with recognized cardiovascular toxicities in some patients. This…

Date: 2025-08-26

The impact of oral semaglutide on glycemic control and weight reduction: a database analysis of dosing effects in Japanese individuals with type 2 diabetes

Abstract: GLP-1 receptor agonists (GLP-1 RAs) reduce cardiovascular events in type 2 diabetes (T2D), and oral formulations improve accessibility. However, their real-world…

Date: 2025-08-26