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Novel pathogenic CTLA4 missense variant associated with autoimmune enteropathy and systemic immune dysregulation

Abstract: Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) haploinsufficiency is a rare monogenic immunodysregulatory disorder that can affect multiple organ systems, leading…

Date: 2026-07-27

Postprandial attenuation of gastric slow waves in anxiety–depression, with and without functional dyspepsia: associations with heart rate variability and sleep quality

Abstract: Functional dyspepsia (FD) commonly coexists with anxiety, depression, and sleep disturbances. However, it remains unclear whether the burden of psychological symptoms…

Date: 2026-07-27

The mediating role of white matter hyperintensity in the association between malnutrition and cognitive impairment in patients with cerebral small vessel disease

Abstract: Malnutrition and white matter hyperintensity (WMH) are both considered risk factors for cognitive impairment in patients with cerebral small vessel disease (CSVD).…

Date: 2026-07-27

A nomogram integrating hemodynamic and inflammatory markers to predict early neurological deterioration after tenecteplase in branch atheromatous disease: an early in-hospital risk stratification model

Abstract: To investigate the risk factors for early neurological deterioration (END) in patients with branch atheromatous disease (BAD) receiving intravenous tenecteplase…

Date: 2026-07-27

Development and validation of a cytokine-based diagnostic model for Kikuchi–Fujimoto disease

Abstract: The diagnosis of Kikuchi–Fujimoto disease (KFD) is challenging, which is mainly based on typical histopathological findings from a lymph node biopsy. We aimed to develop…

Date: 2026-07-27

Free Epstein-Barr virus-induced gene 3 functions as an autonomous immunosuppressive cytokine to maintain immune tolerance

Abstract: Epstein-Barr virus-induced gene 3(EBI3) is conventionally viewed as a subunit of IL-27 and IL-35, yet the function of uncomplexed “free” EBI3 is unknown. We show that…

Date: 2026-07-27

Validation of digital PCR as a complementary tool to MS2 plaque assay for virucidal activity assessment

Abstract: Bacteriophage MS2 is widely applied as a surrogate for pathogenic non-enveloped RNA viruses that are difficult to culture. However, standardized approaches for…

Date: 2026-07-27

Identification of LILRB4 as a regulator of M2c macrophages and a potential immunotherapeutic target in ovarian cancer

Abstract: Ovarian cancer (OC) is the most lethal gynecological malignancy. A deeper insight into tumor microenvironment (TME) interactions is essential for developing novel…

Date: 2026-07-27

Clinical outcomes of intrathecal anti-PD-1 therapy with or without whole-brain radiotherapy in melanoma leptomeningeal metastasis: a multicenter retrospective study

Abstract: Leptomeningeal metastases (LM) from melanoma are rare and associated with dismal outcomes. Intrathecal PD-1 antibody therapy has shown encouraging activity in LM.…

Date: 2026-07-27

Risk factors for severe radiation-induced dermatitis in nasopharyngeal carcinoma patients undergoing radiotherapy

Abstract: Radiation-induced dermatitis (RID) is a common toxicity in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. This study aimed to evaluate the…

Date: 2026-07-27