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Treatment-resistant or difficult-to-treat depression: a consensus on the pharmacotherapy challenges and considerations for the health care system in Greece

Abstract: Introduction: Globally, there is limited scientific consensus on the definition of Treatment Resistant Depression (TRD) or Difficult to Treat Depression (DTD) and even…

Date: 2025-04-28

The occurrence of and risk factors for depressive symptomatology in myocarditis survivors: a cross-sectional survey-based study using machine learning

Abstract: Background: The frequency and impact of depressive symptoms in myocarditis survivors are poorly understood.

Date: 2025-04-28

Validation of the Turkish version of the Developmental Behavior Checklist: a comprehensive tool for assessing emotional, behavioral, and autism spectrum disorders in children and adolescents with intellectual disabilities

Abstract: Introduction: The Developmental Behavior Checklist (DBC) is a standardized tool for evaluating emotional and behavioral concerns in children and adolescents with…

Date: 2025-04-28

Association between RBC folate and lumbar bone mineral density in postmenopausal women, a cross-sectional study from NHANES 2009–2018

Abstract: Background: Postmenopausal women are at an increased risk of bone density reduction, with multiple factors implicated, including folate, a B vitamin whose impact on bone…

Date: 2025-04-28

An immune cell activation signature reflected hepatocellular carcinoma heterogeneity and predicted clinical outcomes

Abstract: Background: The prognosis of hepatocellular carcinoma (HCC) remains challenging, and immune activation plays a critical role in cancer treatment. Identifying reliable…

Date: 2025-04-28

Acupuncture attenuates experimental autoimmune thyroiditis by modulating intestinal microbiota and palmitic acid metabolism

Abstract: Introduction: Autoimmune thyroiditis (AIT) is a common and chronic autoimmune disease. Recent evidence indicates that serum metabolites and dysbiosis of the intestinal…

Date: 2025-04-28

Associations between insulin resistance and low back pain risk in US adults: a cross-sectional study

Abstract: Background: Insulin resistance is one of the major pathophysiological features of type 2 diabetes mellitus. Studies have revealed the association between type 2 diabetes…

Date: 2025-04-28

Novel integrative models to predict the severity of inflammation and fibrosis in patients with drug-induced liver injury

Abstract: Background and aims: Drug-induced liver injury (DILI) is becoming a worldwide emerging problem. However, few studies focus on the diagnostic performance of non-invasive…

Date: 2025-04-28

Integral kidney function assessment in pediatric patients with glycogen storage diseases

Abstract: Introduction: Glycogen storage diseases (GSDs) are a group of hereditary metabolic disorders with variable clinical manifestations, depending on the enzyme and organ…

Date: 2025-04-28