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In vivo RNAi screen and validation reveals Ngp, Hba-a1, and S100a8 as novel inhibitory targets on T lymphocytes in liver cancer

Abstract: Background: Hepatocellular carcinoma (HCC) represents the third deadliest cancer worldwide with limited treatment options. Immune checkpoint inhibitors (ICIs) have…

Date: 2025-04-25

Outcomes and risk factors of COVID-19 in patients with bullous pemphigoid: a cross-sectional study

Abstract: Background: The outcomes of coronavirus disease 2019 (COVID-19) in patients with bullous pemphigoid (BP) remain insufficiently understood. This study aimed to evaluate…

Date: 2025-04-25

Family relationships and personality traits of postural tachycardia syndrome

Abstract: Introduction: Orthostatic intolerance is the name of the disease in Europe and the United States; however, in Japan, it is commonly known as orthostatic dysregulation…

Date: 2025-04-25

Culinary medicine in medical education: a pilot study targeting cancer risk reduction strategies through culinary and lifestyle medicine education

Abstract: Introduction: Culinary Medicine (CM) is an avenue for interdisciplinary nutrition education intervention utilizing the expertise of dietitians, physicians, and other…

Date: 2025-04-25

Single-cell combined transcriptome probes prognostic mechanisms of sialylation-related genes in cervical cancer

Abstract: Introduction: Sialylation has been linked to cervical dysplasia, while its involvement in cervical cancer is uncertain. Hence , the aim of this study was to develop a…

Date: 2025-04-25

Sex differences in pediatric major depressive episodes: a cross-sectional study on psychiatric symptoms in early-onset mood disorders

Abstract: Background: Sex differences in psychiatric symptoms among children and adolescents with a major depressive episode (MDE) are less studied than among adults. Previous…

Date: 2025-04-25

The impact of a home visiting program on the care environment of Brazilian adolescent mothers - an descriptive exploratory study

Abstract: Background: There is evidence of a link between the environment and child development (CD) in early childhood, justifying the importance of studying the characteristics…

Date: 2025-04-25

Effect of diabetes mellitus on physical function in patients with osteoarthritis: a cross-sectional observational study

Abstract: Background: Osteoarthritis (OA) is a common chronic disease among the elderly, causing pain, functional limitations, and a decline in quality of life. Diabetes mellitus…

Date: 2025-04-25

Modified transforaminal epidural steroid injection combined with pulsed radiofrequency: an effective treatment measure for lumbar radiculopathy

Abstract: Background: Lumbar disc herniation (LDH) is a prevalent condition encountered in the clinical diagnosis and management of spinal surgery. Certain people may experience…

Date: 2025-04-25

Development of a prediction model integrating PD-1 and ICOS for early differential diagnosis between autoimmune and viral encephalitis

Abstract: Background: Early diagnosis and treatment for encephalitis are crucial for improving patient outcomes and reducing the economic burden, especially given the overlapping…

Date: 2025-04-25