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Immunotherapy for neuromyelitis optica spectrum disorder: a comparative analysis of efficacy and safety of azathioprine, mycophenolate mofetil, tacrolimus, and rituximab

Abstract: Background and purpose: Biologic therapies are anticipated to dominate the treatment landscape for neuromyelitis optica spectrum disorders (NMOSD) in the future. Despite…

Date: 2025-04-28

Resolution of anti-GAD-associated autoimmune encephalitis in patients treated with efgartigimod

Abstract: Introduction: Temporal lobe epilepsy (TLE) is a significant clinical phenotype of anti-glutamic acid decarboxylase (GAD)-associated disease, which is characterized by…

Date: 2025-04-28

Repeatability, reliability, and stability of eye movement measurements in Parkinson’s disease, cerebellar ataxia, and healthy adults

Abstract: Introduction: Eye movements have been proposed as biomarkers to track disease progression and treatment effects in neurological diseases. Before such variables are used…

Date: 2025-04-28

Single-cell transcriptomics and functional validation revealed PLEKHA5-L as a promoter of growth and migration in brain metastatic melanoma cells

Abstract: Background: Melanoma brain metastasis is an lethal event. Investigating the molecules that potentially promoted melanoma metastasis is important for targeted therapy.

Date: 2025-04-28

Sexual dysfunction and quality of life in cervical and endometrial cancer patients before and after low-dose-rate brachytherapy: a cohort study

Abstract: Background: Research on low-dose-rate (LDR) brachytherapy for gynecological cancer primarily examines treatment toxicity while overlooking aspects such as sexual desire,…

Date: 2025-04-28

The administration sequences of immune checkpoint inhibitors and chemotherapy cause discrete efficacy when treating non-small cell lung cancer: a retrospective study

Abstract: Background: Immune checkpoint inhibitors (ICIs) combined with chemotherapy have become a standard first-line treatment for advanced non-small cell lung cancer (NSCLC).…

Date: 2025-04-28

Joint and independent associations of dietary vitamin intake and prevalence of cardiovascular disease in chronic kidney disease subjects: a cross-sectional analysis

Abstract: Background: Currently, the joint and independent effects of intake of multiple dietary vitamins (including vitamin A, B1, B2, B6, B12, C, D, E, and K) on the prevalence…

Date: 2025-04-28

Can we know more about atherosclerosis in cyanotic patients with congenital heart disease—the potential role of sphingosine-1-phosphate?

Abstract: Background and aims: Progress in cardiology has extended the lifespan of patients with congenital heart defects (CHD). Cyanotic patients are exposed to typical diseases…

Date: 2025-04-28

Monocarboxyoctyl phthalate is associated with platelet count: evidence from a large cross-sectional study

Abstract: Introduction: Phthalates are environmental pollutants that are harmful to human health. However, the impact of phthalate on platelet count remains unclear. This study…

Date: 2025-04-25

Fortified Withaferin A accelerates the transition from fibrovascular to bone remodeling phase during endochondral bone formation to promote ossification

Abstract: Introduction: This study shows that Fortified Withaferin A (FWA, 10% w/w) accelerates bone healing, advancing from the fibrovascular to bone remodeling stage within 12…

Date: 2025-04-25