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Association between triglyceride-glucose index and Helicobacter pylori infection: a cross-sectional study

Abstract: Background: Mounting research suggests that insulin resistance (IR) is associated with Helicobacter pylori (H. pylori) infection. The triglyceride-glucose (TyG) index…

Date: 2025-04-22

Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics

Abstract: Background: Accumulating evidence indicates that elevated polyamine levels are closely linked to tumor initiation and progression. However, the precise role of polyamine…

Date: 2025-04-22

Causal link between mental disorders and gastrointestinal diseases: a Mendelian randomization study

Abstract: Background: Observational research suggests that mental diseases may increase the risk of gastrointestinal diseases. However, the causal link between these conditions…

Date: 2025-04-22

Coinfection with HIV-1 skews iNKT cells toward TCR anergy and limited expansion potential in people with hepatitis C

Abstract: Introduction: Hepatitis C virus (HCV) infection remains a leading cause of morbidity and mortality in people with human immunodeficiency virus (HIV). Liver fibrosis…

Date: 2025-04-22

Multiplex immunophenotyping of human acute myeloid leukemia patients revealed single -cell heterogeneity with special attention on therapy sensitive and therapy resistant subpopulations

Abstract: Introduction: Understanding leukemia-associated immunophenotypes (LAIP) could assist in the design of therapies to ameliorate patient benefits in acute myeloid leukemia…

Date: 2025-04-17

The impact of antibiotic use on outcomes of relapsed/refractory multiple myeloma patients treated with CAR-T therapy

Abstract: Background: In recent years, chimeric antigen receptor (CAR)-T cell therapy has achieved tremendous efficacy in relapsed/refractory multiple myeloma (R/R MM). However,…

Date: 2025-04-17

Global trends and disparities in the burden of heart failure caused by chronic kidney disease: an analysis of the global burden of disease study 2021

Abstract: Background: Heart failure (HF) is a major public health concern, and chronic kidney disease (CKD) plays a significant role in its pathogenesis. Understanding the trends…

Date: 2025-04-17

Long-term outcomes of congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a retrospective study from a tertiary care center in Saudi Arabia

Abstract: Introduction: Data on congenital adrenal hyperplasia (CAH) disorders in the Saudi population are limited. This retrospective study assessed the clinical characteristics…

Date: 2025-04-17

No, either or both parents with metabolic syndrome: comparative study of its impact on sons and daughters

Abstract: Background: Metabolic syndrome (MetS) is known to have parental influence on children’s metabolic health, increasing the risk for the cardiometabolic diseases. However,…

Date: 2025-04-17

Concomitant autoimmunity and late cancers in adult-onset immunodeficiency due to neutralizing anti-IFN-? autoantibodies

Abstract: Background: Opportunistic intramacrophagic infections are well-characterized in adult-onset immunodeficiency associated with neutralizing anti-IFN-? autoantibodies…

Date: 2025-04-17