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Extreme temperatures modulate gene expression in the airway epithelium of the lungs in mice and asthma patients

Abstract: Background: The objective of this study was to examine the effects of extreme temperatures on the gene signature and pathways of airway epithelial cells in mice and…

Date: 2025-04-17

Prenatal opioid exposure alters pain perception and increases long-term health risks in infants with neonatal opioid withdrawal syndrome

Abstract: Background: Opioids are often prescribed for pain relief, yet they pose risks such as addiction, dependence, and overdose. Pregnant women have unique vulnerabilities to…

Date: 2025-04-17

Leveraging a disulfidptosis-based signature to characterize heterogeneity and optimize treatment in multiple myeloma

Abstract: Background: Disulfidptosis is an emerging type of programmed cell death related to ROS accumulation and aberrant disulfide bond formation. Multiple myeloma (MM) is the…

Date: 2025-04-16

Clinical efficacy of Bufei Yishen and Qutan Tongluo Cream on the treatment of patients with stable chronic obstructive pulmonary disease

Abstract: Background: Traditional Chinese medicine has been used for the treatment of chronic obstructive pulmonary disease (COPD). However, the effect of Bufei Yishen and Qutan…

Date: 2025-04-16

Increasing donor kidney age significantly aggravates the negative effect of pretransplant donor-specific anti-HLA antibodies on kidney graft survival

Abstract: Background and hypothesis: The presence of donor-specific anti-HLA antibodies before kidney transplantation (preDSAs) is associated with decreased graft survival. The…

Date: 2025-04-16

Attitudes toward organ donation among university students in the United Arab Emirates: a cross-sectional survey

Abstract: Introduction: Organ transplantation is a vital treatment for end-stage organ failure. However, the shortage of available organs remains a significant challenge…

Date: 2025-04-16

Dynamic changes in peripheral inflammation as a risk factor for perioperative sleep disturbances in elderly patients undergoing laparoscopic hepatobiliary surgery

Abstract: Background: Elderly surgical patients are at high risk of perioperative sleep disturbances (PSD), and the underlying pathogenic mechanisms remain unclear. The…

Date: 2025-04-16

Anesthetic management of folders with severe kyphosis in ankylosing spondylitis: a single-center retrospective case series study

Abstract: Background: Ankylosing spondylitis (AS) is a progressive inflammatory disease causing severe kyphosis, which complicates surgical management and increases complication…

Date: 2025-04-16

Identification and validation of monocyte to macrophage differentiation-associated as a prognostic biomarker in gastric cancer

Abstract: Background: Gastric cancer (GC) has a very poor prognosis as most cases are diagnosed at a late stage, which can be partially attributed to a lack of reliable diagnostic…

Date: 2025-04-16