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Monitoring sexual hormones in women going to high altitude—a pilot study

Abstract: Background: The susceptibility to acute mountain sickness (AMS) in relation to sexual hormones in women remains elusive, partly because hormones could not be…

Date: 2025-03-31

Improvement in breast cancer survival across molecular subtypes in Hungary between 2011 and 2020: a nationwide, retrospective study

Abstract: Background: Despite well-documented clinical differences across breast-cancer (BC) molecular subtypes and relevant changes in therapeutic interventions over the past…

Date: 2025-03-31

Post-carvedilol myocardial function in cats with obstructive hypertrophic cardiomyopathy

Abstract: Introduction: Hypertrophic cardiomyopathy (HCM) is the most prevalent cardiac disease in cats, and one phenotype includes obstructive HCM with dynamic left ventricular…

Date: 2025-03-28

Transcriptomic signatures in peripheral CD4+T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiation

Abstract: Background and purpose: Promoting adaptive immunity with ICIs has drastically improved melanoma prognosis, but not for all patients. Some cases relapse in the first few…

Date: 2025-03-28

Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion

Abstract: Background: Anti-CD19 chimeric antigen receptor T (CAR-T) cell therapy has proven effective for treating relapsed or refractory acute B cell leukemia. However,…

Date: 2025-03-27

Boundary aware microscopic hyperspectral pathology image segmentation network guided by information entropy weight

Abstract: Introduction: Accurate segmentation of lesion tissues in medical microscopic hyperspectral pathological images is crucial for enhancing early tumor diagnosis and…

Date: 2025-03-27

Association of magnesium depletion score with serum anti-aging protein Klotho in the middle-aged and older populations

Abstract: Background: Magnesium deficiency and low levels of the anti-aging protein Klotho have been independently associated with various age-related diseases. The Magnesium…

Date: 2025-03-27

Impact of QazVac vaccination on clinical manifestations and immune responses in post—COVID syndrome: a cross-sectional study

Abstract: Introduction: Post-COVID syndrome, also known as long COVID, has emerged as a major public health concern, affecting a substantial proportion of individuals recovering…

Date: 2025-03-26

Enhanced immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells in 3D culture

Abstract: Introduction: Mesenchymal stem cells (MSCs) have been introduced as a treatment for dogs owing to their immunomodulatory effects. In humans, 3D-cultured MSCs have…

Date: 2025-03-26