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Real-world evidence of baseline soluble CD25 as a prognostic biomarker and indicator of differential EGFR–TKI benefit in stage IV lung adenocarcinoma

Abstract: Outcomes in stage IV lung adenocarcinoma (LUAD) remain heterogeneous despite established genomic and immune biomarkers. We evaluated the prognostic and predictive value…

Date: 2026-07-10

Berberine restrains the expansion of colorectal cancer organoids by blocking cell cycle progression and reducing lipid synthesis

Abstract: Among all the most prevalent malignant gastrointestinal cancers, colorectal cancer (CRC) occurs frequently in all the populations around the world. Despite remarkable…

Date: 2026-07-10

Machine learning-based prognostic model for triple-negative breast cancer with axillary lymph node metastasis

Abstract: Triple-negative breast cancer (TNBC) with axillary lymph node metastasis (ALNM) represents a high-risk population with substantially worse prognosis compared to other…

Date: 2026-07-10

Role of homocysteine, vitamins B12, B6, B1, and folate in Saudi patients with premature acute coronary syndrome

Abstract: Homocysteine (HCY) has been implicated in cardiovascular disease through adverse effects on vascular endothelium, oxidative stress, and thrombogenic pathways. Saudi…

Date: 2026-07-10

Flow-based imaging reveals dissociated monocyte adhesion and transmigration patterns between TNF-? and diabetes-induced vascular inflammation

Abstract: Monocyte–endothelial interactions drive both acute inflammation and chronic vascular disease in type 2 diabetes mellitus (T2DM), yet whether TNF-?–induced and…

Date: 2026-07-10

Association of triglyceride glucose index with cardiovascular autonomic neuropathy in type 2 diabetes mellitus

Abstract: Cardiovascular autonomic neuropathy (CAN), defined as impaired autonomic control of the cardiovascular system, is a highly prevalent yet frequently underdiagnosed…

Date: 2026-07-09

Beyond BMI: insulin resistance emerges as the key metabolic correlate of AMH in PCOS

Abstract: The association between anti-Müllerian hormone (AMH) levels, body weight and insulin resistance in women with polycystic ovary syndrome (PCOS) has been extensively…

Date: 2026-07-09

Twenty-five-year trends in mortality and major morbidity among very low birth weight infants at a Saudi tertiary centre: improving morbidity despite expanding resuscitation at the limits of viability

Abstract: Very low birth weight (VLBW) infants remain at high risk of mortality and major morbidity, yet longitudinal data from Saudi Arabia spanning several decades are scarce.…

Date: 2026-07-09

Parental anxiety levels before and after pediatric cardiology evaluation with echocardiography in asymptomatic children with heart murmurs: a prospective study

Abstract: Cardiac murmurs are common in childhood, yet their detection often triggers significant parental anxiety. This study aimed to measure anxiety levels in parents of…

Date: 2026-07-09

Pharmacologic treatment strategies and association with major neonatal outcomes for patent ductus arteriosus in preterm infants

Abstract: Patent ductus arteriosus (PDA) is common in preterm infants. Although pharmacologic treatment promotes ductal closure, its impact on clinically meaningful outcomes…

Date: 2026-07-09