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Machine learning early risk assessment model for acute kidney injury in critically ill children: a retrospective cohort study

Abstract: Acute kidney injury (AKI) is a common severe complication in intensive care unit (ICU). However, an early risk assessment model that can accurately and promptly predict…

Date: 2026-07-09

Impaired IFN-?-mediated innate and adaptive immunity in Coffin-Siris syndrome type 2: immunological insights from a patient with a recurrent ARID1A mutation

Abstract: Coffin-Siris syndrome type 2 (CSS2), caused by ARID1A mutations, is characterized by neurodevelopmental delay and recurrent infections. The ARID1A p.Ala1077Glu variant…

Date: 2026-07-09

Temporal trends and projected mortality of myocardial infarction and heart failure in the United States, 1999–2035: a CDC WONDER analysis

Abstract: Myocardial infarction (MI) and heart failure (HF) remain major contributors to cardiovascular mortality in the United States. This study analyzed national MI- and…

Date: 2026-07-09

uFlowAM: an unsupervised framework for detection and visualization of abnormal intracardiac microflow on early-pregnancy fetal cardiac microflow imaging

Abstract: Congenital heart disease (CHD) is a clinically important fetal anomaly. Early-pregnancy fetal cardiac microflow imaging (FCMI) can show low-velocity intracardiac flow,…

Date: 2026-07-09

Effectiveness and tolerability of cephalexin and clavulanic acid fixed dose combination, amoxicillin and clavulanic acid fixed dose combination, and azithromycin in patients with pharyngitis in India: a real-world retrospective study from electronic medical records (PHARYSPOR)

Abstract: Acute pharyngitis is a common condition in outpatient departments. Increasing antimicrobial resistance (AMR) necessitates careful prescribing practices. A new fixed-dose…

Date: 2026-07-09

Cardiomyopathy in women with acromegaly: clinical characteristics and associated factors in a Colombian multicenter registry

Abstract: Acromegalic heart disease (AHD) is a common complication of acromegaly; however, evidence specifically focused on women in Latin America remains limited. To characterize…

Date: 2026-07-09

Development and external validation of a composite biomarker-based machine learning model for sarcopenia risk stratification in patients with cardiovascular disease

Abstract: Sarcopenia is common in patients with cardiovascular disease (CVD) and is associated with functional decline and adverse clinical outcomes. However, practical tools for…

Date: 2026-07-09

Development and validation of a risk prediction model for demoralization syndrome in patients with type 2 diabetes

Abstract: Demoralization syndrome (DS), characterized by helplessness, hopelessness, and diminished self-worth, is a common but underrecognized psychological distress in chronic…

Date: 2026-07-09

Investigating the association between low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and the risk of carotid artery plaque in patients with first-ever ischemic stroke based on different glucose metabolic conditions

Abstract: This study investigated the association between the low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio and carotid plaque…

Date: 2026-07-09

Adverse childhood experiences and academic burnout among Chinese traditional medicine students: the serial mediating role of rumination, self-control, and resilience

Abstract: Medical students are vulnerable to academic burnout, particularly those with a history of adverse childhood experiences (ACEs). Although early adversity has been linked…

Date: 2026-07-09