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Generative adversarial networks for balancing and expanding data resources for computer-aided detection in colonoscopy

Abstract: Developing computer-aided detection (CADe) algorithms in colonoscopy requires high-quality databases sourced from real-world data. However, such databases demand costly…

Date: 2026-07-09

Serum immune profiling suggests overlap between IBD patients with joint complaints and patients with spondyloarthritis

Abstract: Inflammatory bowel disease (IBD) and spondyloarthritis (SpA) are strongly associated, and joint complaints are common in patients with IBD. However, it remains unclear…

Date: 2026-07-09

Unique expression pattern of circulating exosomal miRNA correlates with CNS pathology

Abstract: To investigate the total circulating exosome transcriptome in animal models of two different CNS pathologic conditions, autoimmune demyelination and traumatic brain…

Date: 2026-07-09

GATD3A-mediated monocyte homeostasis and compartmentalized erythrocyte alpha-synuclein discriminate early Parkinson’s disease from MSA-P

Abstract: Differentiating early-stage Parkinson’s disease (PD) from the parkinsonian variant of multiple system atrophy (MSA-P) remains a significant challenge due to overlapping…

Date: 2026-07-09

Early arterial blood gas parameters, clinical features, and neuroimaging findings in neonates undergoing therapeutic hypothermia for suspected hypoxic-ischemic encephalopathy: a retrospective single-center study

Abstract: Hypoxic-ischemic encephalopathy (HIE) remains an important cause of neonatal mortality and long-term neurodevelopmental impairment. Although therapeutic hypothermia is…

Date: 2026-07-09

Early prediction of severe autoimmune encephalitis: development and validation of a model incorporating readily available lactate dehydrogenase

Abstract: Autoimmune encephalitis (AE) is a severe neuroinflammatory disease with a substantial risk of progression to critical illness requiring intensive care. Early…

Date: 2026-07-09

Circular RNA circNUP214 serves as a microRNA-31 sponge to promote the progression of myasthenia gravis through NFAT5

Abstract: Myasthenia gravis (MG) is an autoimmune disease driven by autoantibodies targeting the neuromuscular junction, leading to muscle weakness. Although emerging evidence…

Date: 2026-07-09

The toxicity profile and temporal dynamics of dual PD-1/CTLA-4 immune checkpoint blockade: a real-world pharmacovigilance study using the FAERS database

Abstract: Combination therapy with PD-1 and CTLA-4 inhibitors improves survival in advanced cancers but is associated with heightened toxicity. Whether this represents additive…

Date: 2026-07-09

Circulating immune and biochemical markers predict tumor response to immunotherapy in advanced melanoma and lung cancer

Abstract: Peripheral immune biomarkers provide a minimally invasive approach to monitor systemic responses to cancer immunotherapy, yet their predictive value in real-world…

Date: 2026-07-09

Preclinical translational screening of palladium(II)-porphyrin photosensitizers across human and Oncopig bladder cancer cell lines

Abstract: Bladder cancer remains a highly recurrent malignancy with limited long-term response to conventional therapies. The development of new treatments is also hindered by the…

Date: 2026-07-09