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Application of the combined technique of novel transseptal puncture guidewire and steerable sheath in left atrial appendage occlusion: a preliminary feasibility case series

Abstract: Transseptal puncture (TSP) is a critical step in left atrial appendage occlusion (LAAO) but presents certain technical challenges. Conventional puncture needles, due to…

Date: 2026-09-03

Predictive value of heart rate variability for major adverse cardiovascular events after percutaneous coronary intervention in patients with acute coronary syndrome: a retrospective cohort study

Abstract: Acute coronary syndrome (ACS) remains a leading cause of cardiovascular mortality globally. Although percutaneous coronary intervention (PCI) has markedly improved…

Date: 2026-09-03

Preliminary exploration of the value of pericoronary adipose tissue radiomics in identifying high-risk patients with chronic coronary syndrome: a retrospective Chinese cohort study

Abstract: Chronic coronary syndrome (CCS) requires accurate risk stratification for optimized management. Pericoronary adipose tissue (PCAT) inflammation is closely associated…

Date: 2026-09-03

Integrating conformal prediction with machine learning for uncertainty-aware risk stratification in coronary artery disease

Abstract: Predictive models are increasingly used in clinical decision-making in coronary artery disease (CAD). However, most existing models focus on discriminative ability while…

Date: 2026-09-03

Calcitonin gene-related peptide promotes mast cell-mediated neuroimmune inflammation through the CALCRL/RAMP1–JAK3–STAT1 axis in rosacea

Abstract: Rosacea is a chronic inflammatory skin disorder characterized by neurovascular instability and dysregulated innate immunity. Although mast-cell activation is…

Date: 2026-09-02

Prevalence and psychosocial correlates of depressive symptom risk among secondary school students in Saudi Arabia: a mixed-methods study

Abstract: Adolescent depression is a major public health concern with important psychosocial and educational implications. This study examined the distribution of a…

Date: 2026-09-02

Reduced-intensity post-cyclophosphamide-based graft-versus-host disease prophylaxis for umbilical cord blood transplantation: a single-center pilot study

Abstract: Post-cyclophosphamide (PTCy)-based GVHD prophylaxis has shown significant success in haploidentical transplants. The potential of PTCy in adult umbilical blood…

Date: 2026-09-01

Metformin potentiates arsenic disulfide in diffuse large B-cell lymphoma: modulation of BAX/BCL-2 apoptotic pathway and hedgehog pathway

Abstract: Arsenic disulfide (As 2 S 2 ) inhibits proliferation and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cells, its clinical application is constrained by…

Date: 2026-09-01

Effects of a “5?+?2” dietary management model on body composition and behavioral modification in Chinese children with obesity: a prospective, non-randomized controlled trial

Abstract: Continuous energy restriction may be associated with poor adherence and a risk of muscle mass loss in pediatric obesity management. This study evaluated the effects of a…

Date: 2026-09-01

Associations between household solid fuel use, kitchen ventilation, and depressive symptoms among older adults in China: a national cross-sectional study

Abstract: Household solid fuel use has been associated with adverse mental health outcomes among older adults. However, evidence on the association between household solid fuel…

Date: 2026-09-01