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Reduced heart rate variability is associated with disease severity in AL amyloidosis: a retrospective cohort study

Abstract: Autonomic nervous system involvement is common in systemic amyloidosis, yet the clinical relevance of heart rate variability (HRV) in immunoglobulin light-chain (AL)…

Date: 2026-08-27

From transcriptomic profiling to precision oncology: a bibliometric analysis of RNA sequencing in acute myeloid leukemia

Abstract: RNA sequencing (RNA-seq) has become an important tool for investigating the molecular heterogeneity of acute myeloid leukemia (AML); however, the global development and…

Date: 2026-08-27

The double-edged role of SPAG6 in male reproductive toxicity: pro-invasive in leukemia, protective in germ cells

Abstract: Male testis is highly susceptible to irreversible damage from acute myeloid leukemia (AML) infiltration and subsequent chemotherapy. As a gene critical for sperm…

Date: 2026-08-27

Single-cell Raman profiling of B cell differentiation and leukemic transformation with transcriptome inference

Abstract: Label-free profiling of cellular transcriptional and metabolic states during B cell differentiation and malignant transformation remains technically challenging. Raman…

Date: 2026-08-27

Nomogram integrating BRAF V600E, serum biomarkers, and ultrasound features for malignancy risk stratification in C-TIRADS category 3 and 4 thyroid nodules

Abstract: For patients with C-TIRADS 3 or 4 nodules who have undergone fine-needle aspiration cytology (FNAC), subsequent management decisions remain challenging, especially when…

Date: 2026-08-27

Reproductive outcomes following assisted reproductive technology after previous caesarean section: data from the Swiss National Registry

Abstract: Caesarean section rates have risen worldwide, exceeding the rate of 10%–15% recommended by the WHO. This increase is driven by factors such as advanced maternal age,…

Date: 2026-08-27

Insulin resistance evaluated by estimated glucose disposal rate and its association with cardiometabolic risk factors among adolescents in Northeast China

Abstract: Insulin resistance (IR) is a key factor in cardiometabolic diseases, but there are few practical ways to measure it in adolescents. The insulin sensitivity’s surrogate…

Date: 2026-08-27

Extreme phenotype-derived machine learning reveals susceptibility and resilience signatures for severe diabetic retinopathy

Abstract: The mechanisms underlying why some individuals with diabetes develop severe diabetic retinopathy (DR), whereas others remain free of retinal complications despite…

Date: 2026-08-27

Distinct metabolic phenotypes in adolescents with obesity identified by unsupervised learning: associations with insulin resistance and resting energy expenditure

Abstract: Pediatric obesity is characterized by substantial metabolic heterogeneity, including adiposity, insulin resistance, inflammation, and energy metabolism. Traditional…

Date: 2026-08-27

Joint trajectories of adiposity and systemic inflammation and incident diabetes among older adults: a bi-cohort prospective study with mediation analysis

Abstract: Obesity and chronic low-grade inflammation are established risk factors for type 2 diabetes, yet their joint longitudinal evolution and combined contribution to diabetes…

Date: 2026-08-27