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Development of a nomogram for predicting axillary pathologic complete response after neoadjuvant therapy in clinically node-positive breast cancer

Abstract: Reliable and accessible tools for estimating axillary pathologic complete response (ax-pCR) after neoadjuvant therapy (NAT) remain limited. This study evaluated whether…

Date: 2026-08-21

Daily changes in fine particulate matter are associated with acute myocardial infarction hospitalizations: an individual-level time-stratified case-crossover study in Zhongshan, China

Abstract: Acute myocardial infarction (AMI) imposes a substantial and growing burden globally. Short-term exposure to ambient fine particulate matter (PM 2.5 ) has been linked to…

Date: 2026-08-21

Efficacy and safety of left bundle branch area pacing performed with stylet-driven leads

Abstract: Left bundle branch area pacing (LBBAP) has emerged as a physiological pacing strategy. LBBAP has been predominantly performed using the lumen-less lead. This study aims…

Date: 2026-08-21

The impact of lipoprotein(a) determination in cardiovascular risk stratification among people living with HIV

Abstract: Human immunodeficiency virus (HIV) infection has become a chronic condition due to antiretroviral therapy (ART), which has increased life expectancy but is also…

Date: 2026-08-21

Frailty, social disconnection, metabolomic signatures, and incident peripheral artery disease in type 2 diabetes: a prospective cohort study

Abstract: Frailty and social disconnection may increase vascular risk in type 2 diabetes mellitus (T2DM), but their associations with peripheral artery disease (PAD) and related…

Date: 2026-08-21

Association between adverse pregnancy outcomes and incidence of advanced cardiovascular-kidney-metabolic disease: a population-based cohort study

Abstract: Adverse pregnancy outcomes (APOs) are independent risk factors for cardiovascular disease in women. Within the novel cardiovascular-kidney-metabolic (CKM) framework,…

Date: 2026-08-21

Evaluation of regional differences, age, and sex variations in hematological parameters among adolescents in Sudan: a multicenter community-based cross-sectional study

Abstract: Recently, greater attention has been paid to the influence of regional differences, age, and sex on hematological parameters, particularly among adolescents. No such…

Date: 2026-08-20

Integrated bulk and single-cell transcriptomics unveil the role of AHCY in cell cycle regulation of endometrial cancer

Abstract: Although AHCY has been implicated in cancer progression, its specific role in endometrial cancer (EC) remains poorly understood. This study aimed to elucidate the…

Date: 2026-08-20

Shared Treg dysregulation underlies psoriasis vulgaris and atopic dermatitis through the PHF19-PRC2 epigenetic axis

Abstract: Psoriasis vulgaris (PV) and atopic dermatitis (AD) are chronic inflammatory skin diseases characterized by distinct dominant T cell subsets, yet emerging evidence…

Date: 2026-08-20

Integrated bioinformatics analysis reveals convergent molecular signatures associated with SERPINB7 and SERPINA12 deficiency

Abstract: Pathogenic variants in SERPINA12 have recently been identified in patients with palmoplantar keratoderma (PPK). Clinically, SERPINA12-associated PPK shares substantial…

Date: 2026-08-20