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Combined scleral suture-fixated intraocular lens implantation and Iris cerclage pupilloplasty for aphakic eyes with traumatic mydriasis

Abstract: The aim of this study was to present the observational outcomes of scleral suture-fixated intraocular lens (IOL) implantation combined with iris cerclage pupilloplasty…

Date: 2026-09-29

SPHK1 drives pyroptosis via ROS-dependent activation of the NLRP3 inflammasome in non-infectious uveitis

Abstract: Non-infectious uveitis associated with systemic diseases is a sight-threatening inflammatory disorder often associated with dysregulated immune responses and oxidative…

Date: 2026-09-29

Cross-modal fusion of OCT and OCT angiography enface for improved diagnostics of diabetic retinopathy

Abstract: Diabetic retinopathy (DR) is a leading cause of vision impairment worldwide, highlighting the need for accurate and accessible screening tools. Optical Coherence…

Date: 2026-09-29

Orbital decompression with intraorbital corticosteroid injection during the active phase of thyroid eye disease: outcomes in a real-world cohort

Abstract: Orbital decompression is an effective surgery for reducing orbital congestion and proptosis for patients with thyroid eye disease (TED). However, it is commonly stated…

Date: 2026-09-29

Identification of Crohn’s disease-associated molecular signatures by integrative bioinformatics analysis and experimental validation

Abstract: Crohn’s disease (CD) is a chronic inflammatory bowel disease with rising global incidence. Its multifactorial etiology involves genetic, environmental, microbial, and…

Date: 2026-09-29

Integrative single-cell and bulk transcriptomic analysis identify R-loop-associated gene signatures driving immune-inflammatory networks in acute pancreatitis

Abstract: R-loop dysregulation has been implicated in chronic inflammation via DNA damage and cytoplasmic ssDNA release, yet its role in acute pancreatitis (AP) remains to be…

Date: 2026-09-29

Vitamin D screening and targeted supplementation delays liver fibrosis in patients with chronic liver disease: A prospective randomized controlled trial

Abstract: This study aimed to assess the effects of vitamin D screening and targeted supplementation on the progression of liver fibrosis in patients with chronic liver disease…

Date: 2026-09-29

Real-world effectiveness and safety of lasmiditan in patients with migraine: an observational study

Abstract: To evaluate the real-world effectiveness and safety of lasmiditan and determine the factors associated with its effectiveness and adverse effects. We evaluated 75…

Date: 2026-09-29

Multi-modal spatial glycomic analysis of lymphoid aggregates in prostate and pancreatic cancer tissues

Abstract: Altered N-glycosylation plays a critical role in immune regulation, yet the spatial distribution of N-glycans within immune niches of immunologically “cold” tumors…

Date: 2026-09-29

Serum NLRP3 levels are associated with postoperative delirium of elderly patients with lung cancer: an observational analytical study

Abstract: NOD-like receptor protein 3 (NLRP3) regulates the inflammatory response. This study aimed to investigate the relationship between perioperative serum NLRP3 levels and…

Date: 2026-09-29