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Fluoropyrimidine-associated gastrointestinal toxicity: pharmacovigilance reporting signals and in vitro evidence of epithelial injury, barrier impairment, and inflammatory responses

Abstract: Fluoropyrimidines, including 5-fluorouracil (5-FU), capecitabine, tegafur, and trifluridine, are widely used anticancer agents, but their gastrointestinal toxicities…

Date: 2026-09-29

National trends and disparities in mortality involving bladder cancer and substance use disorders in the United States, 1999–2023

Abstract: Although bladder cancer mortality has modestly declined in the United States, co-occurring substance use disorders (SUDs) may contribute to adverse outcomes and widening…

Date: 2026-09-29

Selective rolling circle amplification detection of site-specific DNA 5-hydroxymethylcytosine

Abstract: Site-specific 5-hydroxymethylcytosine (5hmC) has been identified as a potential biomarker involving diagnosis, prognosis, and tumor immune microenvironment across…

Date: 2026-09-29

Context-dependent value of HLA class I diversity in advanced non-small cell lung cancer treated with immune checkpoint blockade

Abstract: Immune checkpoint inhibitors (ICI), alone or in combination with chemotherapy, are the standard first-line treatment for advanced non–small cell lung cancer (NSCLC)…

Date: 2026-09-29

AI-assisted 3D thoracic body composition analysis identifies candidate imaging markers associated with overall survival in older patients with lung cancer receiving radiotherapy

Abstract: Older patients with lung cancer receiving thoracic radiotherapy have heterogeneous outcomes that are not fully captured by conventional clinical descriptors. We…

Date: 2026-09-29

Dynamic serum chloride trajectories predict short- and long-term mortality in patients with malignancies: a retrospective cohort study with external validation

Abstract: Hypochloremia is associated with poor prognosis in various malignant tumors. However, longitudinal trajectories of serum chloride in cancer patients and their…

Date: 2026-09-29

Serum free eicosapentaenoic acid-to-arachidonic acid ratio and long-term risk of major adverse cardiovascular events in patients with coronary artery disease

Abstract: The eicosapentaenoic acid to arachidonic acid (EPA/AA) ratio reflects the balance between n-3 and n-6 polyunsaturated fatty acids. We examined the association between…

Date: 2026-09-29

Radial artery characteristics before and after intra-arterial administration of nitroglycerin and verapamil: an optical coherence tomography study

Abstract: Radial artery dimensions before and after intra-arterial vasodilator administration remain incompletely characterized along the vessel. This study used optical coherence…

Date: 2026-09-29

Night-to-night sleep variability and all-cause and cardiovascular mortality: a prospective cohort study with a complementary in vitro circadian-disruption experiment

Abstract: Irregular sleep–wake patterns may disrupt circadian rhythms, but the dose–response relationship between night-to-night sleep variability and mortality and the…

Date: 2026-09-29

Hematologic follow-up of metamizole-associated Heinz body anemia in dogs

Abstract: Heinz body (HB) anemia is uncommon in dogs. Metamizole is described as a potential trigger in isolated cases. The present study describes the course of…

Date: 2026-09-28