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FDX1 is associated with CALR abundance and JAK–STAT-related inflammatory signaling in myeloproliferative neoplasms

Abstract: Myeloproliferative neoplasms (MPNs) are driven by constitutive cytokine-receptor signaling, yet the metabolic programs associated with driver genotype and inflammatory…

Date: 2026-09-28

Caregiver burden and malnutrition in patients with HIV-associated lymphoma: indirect pathways via symptom distress and family closeness, and a test of resilience as a mediator

Abstract: Malnutrition is a frequent and clinically significant complication in patients with HIV-associated lymphoma, adversely affecting treatment tolerance, prognosis, and…

Date: 2026-09-28

Sex- and age-stratified pharmacovigilance of methotrexate-associated adverse events in pediatric leukemia: a FAERS-based study

Abstract: Pediatric leukemia (PL) is a common malignant tumor in childhood. Methotrexate (MTX) is a widely used chemotherapeutic agent for the treatment of this disease. This…

Date: 2026-09-28

Targeting GPX4 and FSP1 to exploit ferroptotic vulnerability in Ewing sarcoma

Abstract: Ewing sarcoma tumors are defined by chromosomal translocations fusing EWSR1 to ETS family genes, most commonly FLI1 . The resulting EWS::FLI1 fusion oncoprotein drives…

Date: 2026-09-28

Neurological manifestations in metabolic dysfunction syndrome are associated with cumulative metabolic burden beyond hyperglycaemia: a translational study

Abstract: To determine whether neurological injury in metabolic syndrome (MetS) extends beyond hyperglycaemia-driven neuropathy. We employed a translational design combining…

Date: 2026-09-28

Reduced serum Dickkopf-1 levels as a potential supportive biomarker for the development and severity of retinopathy of prematurity: a prospective observational clinical study

Abstract: Retinopathy of prematurity (ROP) involves impaired retinal vascular development, in which the Wnt/?-catenin signaling pathway plays a pivotal role in retinal…

Date: 2026-09-28

Effects of nutritional low phosphorus status caused by extremely low phosphorus diet during lactation and early childhood on endochondral ossification in offspring rats

Abstract: Fetal phosphorus is mainly deposited in bones in late pregnancy. Premature birth interrupts the supply of maternal phosphorus, combined with insufficient reserves,…

Date: 2026-09-28

Caregiver perceptions of telemedicine in developmental and epileptic encephalopathies: a nationwide Spanish survey

Abstract: Developmental and epileptic encephalopathies (DEEs) require intensive and multidisciplinary care. Telemedicine has emerged as a potential tool to improve access and…

Date: 2026-09-28

Adolescent non-suicidal self-injury scale – short form: revision and evaluation of its reliability and validity

Abstract: Non-suicidal self-injury (NSSI) is a clinically significant concern among adolescents, and its accurate yet efficient assessment is essential for research, early…

Date: 2026-09-28

A recommendation model based on profile enhancement for personalized medical expert in online health communities

Abstract: Inefficient matching between medical experts and health advice seekers remains a challenge in online health communities. This study constructs the Recommendation Model…

Date: 2026-09-28