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Neuroprotective potential of the natural polyphenol Procyanidin B2 in spinal cord injury: a comprehensive study utilizing machine learning, network pharmacology, and in vivo validation

Abstract: The secondary injury cascade following spinal cord injury (SCI) drives severe inflammation and tissue destruction. Although the natural polyphenol Procyanidin B2 (PCB2)…

Date: 2026-07-06

Dynamic activation of lytic cell death-related programs identifies CD14 as a candidate hub gene associated with secondary injury after spinal cord injury

Abstract: Secondary spinal cord injury (SCI) involves persistent inflammation, oxidative stress, and multiple forms of programmed cell death. However, the dynamic activation of…

Date: 2026-07-06

Integrated post-GWAS, single-cell, and functional analyses prioritize TCTN2 at an osteoarthritis locus associated with innate immunity-related cartilage remodeling

Abstract: Post-genome-wide association study (GWAS) interpretation of osteoarthritis (OA) increasingly requires integration with single-cell biology because many risk loci likely…

Date: 2026-07-06

Clinical efficacy of STMIPO in the management of distal one-third fibular fractures

Abstract: Second to minimally invasive plates osteosynthesis (STMIPO) is a novel surgical technique that combines the small incision, minimally invasive, and aesthetic advantages…

Date: 2026-07-06

Structured therapeutic exercise program effect on PROM and muscle mass in dogs with osteoarthritis: a prospective clinical study

Abstract: Degenerative joint disease, namely osteoarthritis, represents a major cause of chronic pain and functional limitation in dogs. Although rehabilitation is widely…

Date: 2026-07-06

Histopathological features of gastric map-like redness under image-enhanced endoscopy

Abstract: Map-like redness (MLR) is a characteristic feature of gastritis after Helicobacter pylori ( H. pylori ) eradication and independent risk factor of gastric cancer after…

Date: 2026-07-06

RNF213 marks a regulatory T-cell subset associated with ulcerative colitis

Abstract: Ulcerative colitis (UC) is a nonspecific autoimmune disease, the etiology and pathogenesis of which remain unclear. Identifying new disease targets could inform clinical…

Date: 2026-07-06

Correlations of systemic immune-inflammation index and systemic inflammation response index with the risk for early-onset post-stroke depression in patients with minor stroke: a prospective observational study

Abstract: Inflammation plays a pivotal role in the pathophysiology of post-stroke depression (PSD). However, the relationship between novel systemic inflammatory indices-the…

Date: 2026-07-06

Borrelia miyamotoi infection negatively impacts pregnancy outcomes in immunodeficient mice

Abstract: Soft tick relapsing fever (RF) infections cause adverse pregnancy outcomes, but the impact of hard tick RF on pregnancy is unknown. We assessed pregnancy outcomes in a…

Date: 2026-07-06

Psychological burden in anaphylaxis: a study on alexithymia and quality of life

Abstract: This study examines the impact of psychological burden on quality of life (QoL) in patients with anaphylaxis, assessing the relationship between alexithymia, QoL, and…

Date: 2026-07-06