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Economic value of finotonlimab plus bevacizumab versus sorafenib for first-line treatment of unresectable hepatocellular carcinoma in China and the United States

Abstract: Finotonlimab combined with bevacizumab demonstrated superior progression-free survival and overall survival compared with sorafenib in patients with unresectable…

Date: 2026-07-06

Assessing the risk of adverse drug events from combining aromatase inhibitors with CDK4/6 inhibitors using the FAERS and JADER databases

Abstract: Reports of adverse drug events (ADEs) involving aromatase inhibitors (AIs) and cyclin-dependent kinase 4/6 (CDK4/6) inhibitors exist, but a comprehensive assessment of…

Date: 2026-07-06

Target-prioritized IMRT for nasopharyngeal carcinoma with tumor proximity to the spinal cord: clinical feasibility and long-term outcomes

Abstract: For locally advanced nasopharyngeal carcinoma (NPC) with tumor close to the cervical spinal cord, strict spinal cord constraints may compromise target coverage. We…

Date: 2026-07-06

Longitudinal changes in the relative toxicity of FDA-approved oncology therapeutics: evidence from paired initial and updated RCT reports

Abstract: A growing share of oncology drugs receive FDA approval via expedited pathways based on interim RCT analyses, leaving safety data relatively immature at approval. Whether…

Date: 2026-07-06

From proteome-wide Mendelian randomization and multi-omics integration to functional validation: TGFB3 as a prioritized candidate in gastric adenocarcinoma

Abstract: Gastric adenocarcinoma lacks robust circulating biomarkers and tractable targets. We assessed whether genetically predicted plasma protein levels influence disease risk…

Date: 2026-07-06

The effects of brain radiotherapy combined with immunotherapy and chemotherapy for driver gene-negative non-small-cell lung cancer with brain metastases

Abstract: Brain metastases (BM) are highly prevalent in advanced non-small cell lung cancer (NSCLC); however, therapeutic options remain limited and suboptimal for driver…

Date: 2026-07-06

Histopathological biomarkers of immunotherapy outcome in advanced colorectal cancer: a multicentre retrospective study

Abstract: Immune checkpoint inhibitors (ICIs) have transformed the treatment of advanced colorectal cancer (aCRC), but clinical benefit remains largely confined to patients with…

Date: 2026-07-06

Machine learning for chemotherapy decision-making in breast cancer using large language model

Abstract: Breast cancer chemotherapy decision-making remains challenging due to biological heterogeneity and variability in clinical practice. This study proposes a hybrid…

Date: 2026-07-06

Prognostic significance of the advanced lung cancer inflammation index for long-term mortality in patients with acute myocardial infarction and diabetes

Abstract: The advanced Lung Cancer Inflammation Index (ALI) is a novel composite marker integrating nutritional, metabolic, and inflammatory status. This study aimed to…

Date: 2026-07-06

Effectiveness of structured nursing interventions in reducing complication related morbidity in leukemia patients undergoing hematopoietic stem cell transplantation

Abstract: Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for leukemia but is associated with high rates of complication-related morbidity,…

Date: 2026-07-03