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Efficacy and safety of stereotactic radiotherapy in patients with HER2-positive breast cancer brain metastases following intracranial oligoprogression

Abstract: Tyrosine kinase inhibitors (TKIs) demonstrate clear therapeutic effects in patients with HER2?positive breast cancer complicated by brain metastases. However, the…

Date: 2026-06-19

Proteasome inhibition induces a BRCAness-like state and sensitises HR-proficient ovarian cancer models to PARP inhibitors

Abstract: Poly (ADP-ribose) polymerase inhibitors (PARPi) have improved outcomes in ovarian cancer with homologous recombination deficiency (HRD). However, approximately half of…

Date: 2026-06-19

Single dose of 5 Gy can damage erythrocytes and consequently induces lymphocyte depletion in spleen and circulating blood

Abstract: Radiation-induced lymphopenia (RIL) has been well known to associate with poor patient prognosis. Based on interesting findings in our previous study, we hypothesize…

Date: 2026-06-19

Quality and reliability of cardiac rehabilitation-related short Chinese videos on Douyin and Bilibili: a cross-sectional content analysis

Abstract: Social media platforms have emerged as prominent channels for disseminating cardiovascular health information. However, the accuracy, completeness, and clinical…

Date: 2026-06-19

“Pericoronary adipose tissue attenuation as a marker of global coronary inflammation rather than lesion-specific risk”

Abstract: Pericoronary adipose tissue (PCAT) attenuation is a non-invasive imaging marker of coronary vascular inflammation. However, its relationship with clinical outcomes and…

Date: 2026-06-19

Immunotherapy with or without low-intensity chemotherapy versus conventional chemotherapy as first-line treatment for newly diagnosed B-ALL patients fit for intensive chemotherapy: a propensity score-matched study

Abstract: For B-cell acute lymphoblastic leukemia (B-ALL), the dominance of traditional chemotherapy is being rewritten, with multiple promising novel treatment approaches…

Date: 2026-06-18

Obinutuzumab versus rituximab-based chemotherapy in high-tumor burden indolent B-cell lymphoma: a real-world comparative study

Abstract: Patients with previously untreated follicular lymphoma (FL) or marginal zone lymphoma (MZL) with high-tumor burden represent a subset with unfavorable prognosis.…

Date: 2026-06-18

Estimated five-year survival and direct healthcare costs of adult patients with gastric cancer: real-world evidence from a tertiary hospital in Colombia

Abstract: Gastric cancer remains a major cause of cancer mortality worldwide, particularly in middle-income countries, where late diagnosis is frequent and information on its…

Date: 2026-06-18

Real-world effectiveness and safety of carfilzomib, pomalidomide, and dexamethasone in relapsed/refractory multiple myeloma: a retrospective analysis from China

Abstract: Pomalidomide, a next-generation immunomodulatory drug (IMiD), and carfilzomib, a novel proteasome inhibitor (PI), have been separately approved in combination regimens…

Date: 2026-06-18

A novel inflammatory-nutritional index: NPAR-correlates with the severity of type 2 diabetic foot ulcers

Abstract: The neutrophil-percentage-to-albumin ratio (NPAR), an inflammatory-nutritional biomarker, has prognostic value in various diseases, but its relationship with DFU…

Date: 2026-06-18