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Advanced computer-aided detection system exhibits no more false positives than experienced endoscopists in an image-based comparative study of colon polyps

Abstract: The presence of computer-aided detection (CADe) false positives (FPs) may pose a hurdle to endoscopists’ confidence in, and acceptance of this technology. However,…

Date: 2026-06-11

Deoxycholic acid promotes anxiety- and depression-like behaviors in mice via modulation of the gut microbial metabolite indole-3-propionic acid

Abstract: High-fat diet (HFD)-associated anxiety- and depression-like behaviors are closely linked to disturbances in the gut–brain axis; however, the peripheral signaling…

Date: 2026-06-11

A single-cell atlas of ulcerative colitis reveals neutrophil–stromal circuits linked to biologic therapy resistance

Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by immune cell infiltration, crypt erosion, and severe ulceration. In phase 3 studies with…

Date: 2026-06-11

Risk factors for esophageal stricture after circumferential endoscopic submucosal dissection: a preliminary, multicenter, retrospective, case-control study

Abstract: Post-circumferential endoscopic submucosal dissection (cESD) esophageal stricture remains a refractory complication despite combined steroid therapy (CST). The…

Date: 2026-06-11

Incidence, prevalence, and prognostic impact of sarcopenia on hepatic and cardiovascular outcomes in non-cirrhotic metabolic dysfunction–associated steatotic liver disease

Abstract: Sarcopenia is increasingly recognized as a clinically relevant comorbidity in metabolic dysfunction–associated steatotic liver disease (MASLD), yet its epidemiology and…

Date: 2026-06-11

Clinical features of type A aortic dissection initially presenting with neurological symptoms: a single-center case series

Abstract: Aortic dissection, a life-threatening condition, may present with neurological symptoms mimicking acute stroke, leading to delayed diagnosis and inappropriate…

Date: 2026-06-11

Longitudinal motor function and biomarker correlates in treated adult spinal muscular atrophy: a single-center cohort study

Abstract: Long-term clinical trajectories and accessible biomarkers in adult spinal muscular atrophy (SMA) remain insufficiently characterized under real-world treatment…

Date: 2026-06-11

Napkin-ring sign plaques are associated with clinical outcome in patients with acute ischemic stroke after endovascular therapy

Abstract: Few studies have investigated the association between the carotid artery napkin ring sign (NRS) and acute ischemic stroke (AIS). This study investigated whether the…

Date: 2026-06-11

Vitamin D supports activated CD4 + T-cell proliferation through enhanced glutaminolysis

Abstract: Vitamin D (VitD) is an important immunometabolic regulator of T cell function. Its active form, 1,25-dihydroxyvitamin D 3 , signals through the VitD receptor (VDR),…

Date: 2026-06-11

Antigen-scaffolds loaded with hyper-stable neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy

Abstract: Adoptive cell therapy (ACT) has shown promising results in cancer treatment, however, achieving effective ex vivo expansion of potent, functionally active, and cytotoxic…

Date: 2026-06-11