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Sponge-like sonographic pattern of the spleen in immune dysregulation disorders

Abstract: Although splenic ultrasound (US) assessment is periodically performed in most patients with inborn error of immunity (IEI), splenic microtexture has not been…

Date: 2026-06-15

Pretreatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as prognostic biomarkers for neuroblastoma risk stratification

Abstract: Neuroblastoma (NB) is the most common extracranial solid tumor in children, accounting for approximately 15% of pediatric oncology mortality. While risk-stratified…

Date: 2026-06-15

Endothelial cell damage in patients with acute graft versus host disease receiving treatment with extracorporeal photopheresis

Abstract: Extracorporeal photopheresis (ECP) is a safe, effective treatment for steroid-refractory acute GVHD (SR-aGVHD). Endothelial damage is a pathological substrate of aGVHD.…

Date: 2026-06-15

Association of serum coiled-coil domain containing protein 11 levels with coronary artery disease

Abstract: This study aimed to assess the association between circulating levels of coiled coil domain containing protein 11 (CCDC11) and coronary artery disease (CAD). A total of…

Date: 2026-06-15

A preliminary study on the combined assessment of 25-hydroxyvitamin D and thyroid function for predicting diabetic foot risk and amputation in type 2 diabetes

Abstract: To examine the disparities in 25-hydroxyvitamin D (25OH-vitD) levels and thyroid function between patients with type 2 diabetic foot (DF) and those with type 2…

Date: 2026-06-15

Clinical and genotypic analysis of 79 children with methylmalonic acidemia: a retrospective single-center study in China

Abstract: Methylmalonic acidemia (MMA) is a common hereditary disorder affecting infants and children. This study investigated the onset age, phenotypes, genotypes, and…

Date: 2026-06-15

Development and validation of diagnostic prediction models for central precocious puberty in girls based on machine learning: a multicenter retrospective study

Abstract: We developed novel diagnostic prediction models for central precocious puberty (CPP) diagnosis in girls based on machine learning. In this retrospective study, 2148…

Date: 2026-06-15

Dominant T cell receptor clonotypes in adrenocorticotropic hormone-secreting pituitary carcinoma are the highest-frequency clones among CD4 + and CD8 + cells in peripheral blood during effective anti-PD-1 therapy

Abstract: Pituitary carcinoma is a rare and highly aggressive tumor. While anti-programmed cell death-1 (PD-1) therapy has shown efficacy in some cases, the factors that predict a…

Date: 2026-06-15

The exploration and research on the establishment of an early risk assessment system for high-risk diabetic feet

Abstract: To develop an early risk assessment system for high-risk diabetic feet. The system framework was established through literature review and two rounds of Delphi expert…

Date: 2026-06-15

?-cell SLC38A5 supports amino acid-induced ?-cell proliferation and glucagon secretion

Abstract: Pancreatic ? cells are key regulators of glucose homeostasis, and dysregulated glucagon secretion contributes to hyperglycemia in diabetes. Amino acids strongly…

Date: 2026-06-15