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Targeting Bruton tyrosine kinase with acalabrutinib attenuates murine sclerodermatous chronic graft versus host disease

Abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the only curative option for certain malignant hematopoietic disorders, yet its benefits are…

Date: 2026-06-11

Viable CAR T-cells remain detectable in cerebrospinal fluid in patients with grade ?3 ICANS despite corticosteroid therapy

Abstract: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a severe complication of CAR T-cell therapy. Although CAR T-cells have been detected in cerebrospinal…

Date: 2026-06-11

Clinical outcomes of cancer patients with pre-existing autoimmune thyroid disease treated with PD-(L)-1 inhibitors: a propensity score methodology with inverse probability of treatment weighting retrospective study

Abstract: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. However, these therapies are associated with immune-related adverse events (irAEs), with…

Date: 2026-06-11

Plasma asymmetric dimethylarginine and its association with cardiovascular risk factors in Vietnamese patients before and after kidney transplantation, 2018–2022

Abstract: Asymmetric dimethylarginine (ADMA) levels in patients with chronic kidney disease (CKD) are associated with cardiovascular events and mortality following kidney…

Date: 2026-06-11

Disease site as an independent predictor of survival in radioiodine-refractory thyroid cancer

Abstract: Differentiated advanced thyroid carcinoma (DATC) is rare, accounting for ~5% of thyroid tumors, including radioiodine-refractory thyroid tumors (RAI-R-TC) and thyroid…

Date: 2026-06-11

Clinical characteristics and severity of concomitant atopic dermatitis in adults with asthma: a nationwide population-based registry study

Abstract: Atopic dermatitis (AD) often coexists with asthma, but the characteristics of AD in adults with asthma are largely unknown. The objective of this work was to examine the…

Date: 2026-06-11

Erxiekang emplastra as adjunctive therapy for acute gastroenteritis in children: a single-center retrospective cohort study

Abstract: Standard treatments for pediatric acute gastroenteritis (AGE) have critical limitations in symptom control and medication adherence among young children. This study…

Date: 2026-06-11

Chemical profiling of Staurogyne stenophylla via UPLC-HRMS and in silico investigation into its anti-inflammatory potential

Abstract: Staurogyne stenophylla (Hemsl.) C. B. Clarke ex S. Moore ( S. stenophylla ) has long been recognized in traditional folk medicine for its anti-inflammatory properties.…

Date: 2026-06-11

Preliminary evaluation of DeepSeek-R1 and GPT-5.3 in selected PET/CT clinical scenarios: patient preparation, report interpretation, and diagnostic reasoning

Abstract: To evaluate the performance of DeepSeek (R1 version), an open-source large language model, in three core clinical scenarios: answering patients’ common questions,…

Date: 2026-06-11

Immune - cell death index in hepatocellular carcinoma: a multi-omics and machine learning study for prognosis and immunotherapy prediction

Abstract: The heterogeneity of hepatocellular carcinoma (HCC) and individual disparities in immunotherapy response necessitate the urgent development of accurate evaluation tools.…

Date: 2026-06-11