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A disulfide-bridged single-stranded DNA nanotube for co-delivery of siRNA and chemotherapeutics in ovarian cancer therapy

Abstract: Using DNA nanotechnology, we designed a disulfide-bridged single-stranded DNA nanotube (SS-DNT) functionalized with external aptamers for targeting, and encapsulating…

Date: 2026-05-28

Exercise during pregnancy and infant body mass index during the first year of life: a secondary per-protocol analysis of a randomized clinical trial

Abstract: Maternal lifestyle during pregnancy may influence infant growth trajectories. Prenatal exercise improves maternal outcomes, but associations with infant Body Mass Index…

Date: 2026-05-28

Preoperative low Geriatric Nutritional Risk Index increases intensive care unit admission risk in patients undergoing gastrointestinal tumor surgery

Abstract: Gastrointestinal tumors are highly prevalent malignant tumors worldwide, and surgery is their primary treatment modality. Although the Geriatric Nutritional Risk Index…

Date: 2026-05-28

Clinician and simulated patient perspectives on ambient AI scribes in psychiatric consultations: a qualitative study

Abstract: Documentation burden contributes significantly to psychiatric clinician burnout, with psychiatrists spending an average of three hours per workday on administrative…

Date: 2026-05-28

Predicting ordinal clinical outcomes in at-risk mental states: a multimodal approach

Abstract: Clinical outcomes in individuals with at-risk mental states (ARMS) are heterogeneous and extend beyond the simple dichotomy between transition and non-transition to…

Date: 2026-05-28

Safety signals of perfluorohexyloctane ophthalmic solution in patients with dry eye disease

Abstract: Dry eye disease (DED) is a common ocular surface disorder with limitations in conventional therapies. Perfluorohexyloctane ophthalmic solution, a novel formulation, has…

Date: 2026-05-28

The modified woodward procedure via a limited incision for Sprengel deformity: a retrospective study on efficacy and cosmesis

Abstract: The Woodward procedure is a standard surgical treatment for Sprengel deformity (SD), but its classic execution requires extensive tissue dissection. This study aimed to…

Date: 2026-05-28

The overlooked burden: associations between high-noise environments and scrub nurse wellbeing and performance

Abstract: Operating room noise is a significant occupational hazard affecting healthcare professionals, but the specific consequences for scrub nurses have been largely…

Date: 2026-05-28

C-reactive protein to albumin ratio as a predictor of early postoperative wound complications in patients undergoing posterior lumbar spine surgery

Abstract: Early postoperative wound complications remain a significant challenge following posterior lumbar spine surgery. The C-reactive protein to albumin ratio (CAR) has…

Date: 2026-05-28

Comparison of clinical efficacy between endoscope-assisted oblique lumbar interbody fusion and posterior lumbar interbody fusion in the treatment of lumbar degenerative diseases

Abstract: To compare the clinical efficacy of endoscope-assisted oblique lumbar interbody fusion (Endo-OLIF) with posterior lumbar interbody fusion (PLIF) in the treatment of…

Date: 2026-05-28