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Comparison of the predictive value of CONUT, NLR, and PNI for 6-month and 1-year mortality in middle-aged and older adults with hip fractures: a retrospective study

Abstract: This study aimed to compare the predictive value of three preoperative nutritional status scores—Controlling Nutritional Status (CONUT) score, Neutrophil-to-Lymphocyte…

Date: 2026-05-28

From algorithm to verification: based on network toxicology and machine learning, the immunomodulatory role of IGFBP1/MKI67/C9 in perfluorooctanoic acid-induced osteoarthritis was discovered, and a diagnostic model was constructed

Abstract: Perfluorooctanoic acid (PFOA), a widespread persistent environmental contaminant, has been associated with osteoarthritis (OA) onset and progression, though mechanisms…

Date: 2026-05-28

Impact of short-term online continuing education on gastroesophageal reflux disease on the cognitive level and diagnostic and therapeutic behaviors of physicians in medical consortiums

Abstract: To explore the impact of short-term online continuing education on gastroesophageal reflux disease (GERD) on the cognitive level, diagnostic and therapeutic behaviors of…

Date: 2026-05-28

Preoperative malnutrition is associated with suppressed intratumoral T cell function and distinct tumor-associated microbiota in colorectal cancer: a prospective pilot study

Abstract: Cancer-related malnutrition significantly reduces therapeutic effectiveness, lowers chemotherapy tolerance, and impairs immunotherapy efficacy. Monitoring nutritional…

Date: 2026-05-28

Association of red blood cell distribution width combined with alanine aminotransferase with gastrointestinal hemorrhage in patients with acute pancreatitis: a retrospective MIMIC-IV study

Abstract: Readmission is common in acute pancreatitis (AP), with a rate of about 20%. Acute kidney injury (AKI), shock, and gastrointestinal (GI) hemorrhage are serious…

Date: 2026-05-28

Gastrointestinal dysfunction score for mortality prediction in intensive care unit patients with pre-existing digestive system disease: a prospective observational study

Abstract: Gastrointestinal (GI) dysfunction has been increasingly recognized as a common and clinically important problem in patients in the Intensive Care Unit (ICU). GI…

Date: 2026-05-28

Study of JCAD for prognosis and immune infiltration in hepatocellular carcinoma

Abstract: Hepatocellular carcinoma (HCC) remains a common malignant tumor with high morbidity and mortality. Junctional protein associated with coronary artery disease (JCAD), a…

Date: 2026-05-28

Development of automated machine learning models in predicting colorectal adenoma in metabolic-associated steatotic liver disease

Abstract: Metabolic-associated steatotic liver disease (MASLD) is recognized as the most common chronic liver disease worldwide. Identification of colorectal adenoma in MASLD is…

Date: 2026-05-28

Delphi consensus on the real-world application of the updated diagnostic and treatment guidelines for migraine in Asia Pacific

Abstract: Although diagnostic criteria and treatment guidelines for migraine are well-established, care remains suboptimal due to frequent misdiagnosis and undertreatment. This…

Date: 2026-05-28

The potential involvement of FABP4 in rheumatoid arthritis-associated osteoporosis: a comprehensive bioinformatics analysis and experimental validation

Abstract: This study investigates the role and underlying mechanism of FABP4 in RA secondary OP by examining its correlation with the condition. DEGs related to RA and OP were…

Date: 2026-05-28