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Gut microbiome functional pathways outperform taxonomic profiles in predicting immune checkpoint inhibitor response in non-small cell lung cancer: an interpretable machine learning approach with SHAP

Abstract: Lung cancer remains the leading cause of cancer mortality worldwide, with non-small cell lung cancer (NSCLC) accounting for the majority of cases. Although immune…

Date: 2026-05-15

Phase I/II, open-label, multicenter study of durvalumab in combination with tremelimumab in pediatric patients with advanced solid tumors

Abstract: We conducted a phase I/II study to evaluate durvalumab (D; anti-PD-L1) in combination with tremelimumab (T; anti–cytotoxic T-lymphocyte antigen 4) in pediatric patients…

Date: 2026-05-15

Neoadjuvant camrelizumab in combination with chemotherapy followed by sequential radical surgery for locally advanced esophageal squamous cell carcinoma: postoperative pathological remission characteristics and influencing factors

Abstract: Neoadjuvant camrelizumab combined with chemotherapy has shown favorable efficacy and safety profiles in the treatment of locally advanced esophageal squamous cell…

Date: 2026-05-15

Prognostic significance of atrial functional mitral regurgitation in patients with HFpEF and end-stage renal disease

Abstract: Atrial functional mitral regurgitation (AFMR) is common in patients with heart failure with preserved ejection fraction (HFpEF) and end-stage renal disease (ESRD)…

Date: 2026-05-15

Integrative multivariate genomic analysis reveals shared genetic determinants and druggable targets for vascular calcification

Abstract: Vascular calcification (VC), characterized by calcium deposition in arterial walls, is a major risk factor for cardiovascular morbidity and mortality. While genome-wide…

Date: 2026-05-15

Influence of nursing cardiac rehabilitation on cardiac function and quality of life in patients with coronary heart disease after percutaneous coronary intervention

Abstract: With the widespread application of Percutaneous coronary intervention (PCI) is widely used to treat coronary heart disease (CHD). Although it can effectively open…

Date: 2026-05-15

Systemic immune-inflammation Index and blood pressure control are independent and interactive predictors of atrial fibrillation recurrence after ablation

Abstract: Atrial fibrillation (AF) recurrence remains a major limitation after radiofrequency catheter ablation (RFCA), especially in patients with hypertension. Systemic…

Date: 2026-05-15

Integrated biomarkers and cardiac phenotypes associated with atrial fibrillation: evidence from real-world hospital data

Abstract: This study aimed to investigate the association between the B-type natriuretic peptide (BNP)/ left ventricular ejection fraction (LVEF) and atrial fibrillation (AF) and…

Date: 2026-05-15

CMV-specific T-cell receptor-engineered T-cell therapy as first-line treatment for CMV reactivation after haploidentical hematopoietic stem cell transplantation: a phase 2 trial

Abstract: Cytomegalovirus (CMV) reactivation is a major cause of mortality following haploidentical hematopoietic stem cell transplantation (haplo-HSCT). The application of…

Date: 2026-05-14

Serum Syndecan-1: a potent prognostic biomarker for transplant outcomes

Abstract: Post-transplant–associated complications arising from endothelial injury, such as sinusoidal obstruction syndrome (SOS) and transplant-associated thrombotic…

Date: 2026-05-14