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Dynamic changes in peripheral blood lymphocyte subsets predict the efficacy and prognosis of immune checkpoint inhibitors in metastatic osteosarcoma

Abstract: Osteosarcoma (OSA) remains the most common primary malignant bone tumor in children and adolescents, with a poor prognosis for metastatic disease. While immune…

Date: 2026-05-13

Rice body synovitis in children: a retrospective study of 6 cases and a systematic literature review of the last two decades (2006–2026)

Abstract: Rice body synovitis (RBS), historically linked to tuberculosis, is increasingly recognized as an articular manifestation of autoimmune diseases in children, particularly…

Date: 2026-05-13

Predictive model for in-hospital acute cerebral infarction in patients with acute gastrointestinal bleeding: a retrospective cohort study

Abstract: Acute gastrointestinal bleeding (GIB) is a common emergency in gastroenterology and may be accompanied by blood loss, anemia, systemic inflammation, and hemodynamic…

Date: 2026-05-13

Incidence of Clostridium difficile infection and enteric pathogens in children with inflammatory bowel disease presenting with disease exacerbation

Abstract: Pediatric patients with inflammatory bowel disease (IBD) are at increased risk of gastrointestinal infections including Clostridioides difficile infection (CDI), which…

Date: 2026-05-13

A preclinical investigation into the potential associations of geraniin with ulcerative colitis alleviation through integrated multi-omics and in vivo analysis

Abstract: This study aims to investigate the potential molecular mechanisms and alleviating effects of geraniin, a natural polyphenol compound, within a murine model of ulcerative…

Date: 2026-05-13

Disease-specific divergence of inflammatory and metabolic biomarkers in neurocritical neuromuscular disorders

Abstract: Myasthenia gravis (MG) and Guillain–Barré syndrome (GBS) are immune mediated neuromuscular disorders that may require intensive immunotherapy and respiratory support.…

Date: 2026-05-13

Association of steroid regimens and withdrawal with relapse risk in myasthenia gravis: a real-world cohort study

Abstract: Corticosteroids (steroids) are the first-line immunotherapy for myasthenia gravis (MG), but the optimal steroid dosing regimen and effects of discontinuation remain…

Date: 2026-05-13

Machine learning-based prediction of ischemic cardio-cerebrovascular events after endovascular or microsurgical treatment of unruptured intracranial aneurysms and risk stratification by the early post-treatment triglyceride-glucose index

Abstract: Ischemic cardio-cerebrovascular events (ICCEs), including acute coronary syndrome and ischemic cerebral infarction, remain clinically important complications after…

Date: 2026-05-13

Three-year real-world effectiveness, treatment persistence, and planned discontinuation of anti-calcitonin gene-related peptide monoclonal antibodies for migraine prevention: a single-center cohort from Japan

Abstract: Long-term real-world evidence beyond 24?months for anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies is scarce, particularly regarding treatment…

Date: 2026-05-13

Proportions, trends, and outcomes of posterior circulation ischemic stroke in the United States

Abstract: Posterior circulation ischemic stroke has been previously studied in single-center and multicenter registries. The contemporary proportions, trends, and outcomes of…

Date: 2026-05-13