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The significance of CEACAM60, a carcinoembryonic antigen (CEA) homolog, as a tumor antigen in the porcine cancer model

Abstract: Translational medicine remains one of the central challenges in modern biomedical research. A major bottleneck in this field is the limited availability of suitable…

Date: 2026-05-13

Baseline serum cortisol as a prognostic biomarker for immune checkpoint inhibitor therapy in advanced gastric cancer

Abstract: Immune checkpoint inhibitors (ICIs) have transformed the treatment of advanced gastric cancer (AGC), but only a subset of patients benefit. Validated prognostic…

Date: 2026-05-13

Interrelations of disease activity, health-related quality of life, and mental health in axial spondyloarthritis: the Rheuma-VOR cohort

Abstract: Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease characterized by pain and stiffness of the axial skeleton, peripheral manifestations like…

Date: 2026-05-13

Rehmannioside A alleviates neuroinflammation and cognitive impairments after traumatic brain injury by suppressing microglial activation via the MAPK/NF-?B pathway

Abstract: Traumatic brain injury (TBI) triggers a robust neuroinflammatory response characterized by microglial activation, which propagates secondary neuronal damage and…

Date: 2026-05-13

New insights gained from a decade long multi-center retrospective study on the management strategy for heterotopic pregnancy: expectant management is worth considering in patients without vaginal bleeding

Abstract: Heterotopic pregnancy (HP) is a rare but clinically challenging condition because treatment of the ectopic component must be balanced against preservation of the…

Date: 2026-05-13

Assessment of treatment outcomes in patients with breast cancer who underwent mastectomy and breast reconstruction with sparing of the areola-nipple complex – single-center analysis

Abstract: Despite significant improvements in early detection of breast cancer, some patients still require mastectomy. One clinical problem currently being analyzed is the…

Date: 2026-05-13

Prediction of clinical outcomes of advanced cutaneous squamous cell carcinoma to PD-1 inhibition directly from histopathology slides using inferred transcriptomics

Abstract: Metastatic or locally advanced cutaneous squamous cell carcinoma (cSCC) that is not amenable to local therapy is treated with programmed death-1 (PD-1) inhibitors.…

Date: 2026-05-13

Predicting survival of patients treated with antibody–drug conjugates in early-phase clinical trials using AI-quantified 3D body composition on CT scans

Abstract: Body composition has a significant impact on the prognosis of cancer patients. However, little is known about its impact on the efficacy and safety of antibody–drug…

Date: 2026-05-13

Prediction of myelosuppression risk in postoperative cervical cancer patients undergoing concurrent chemoradiotherapy using machine learning models

Abstract: By integrating clinical features and pelvic bone marrow dose–volume parameters, this study developed and compared multiple machine learning models to predict the risk of…

Date: 2026-05-13

A three-gene expression signature predicts lymph node metastasis in cervical squamous cell carcinoma: development and validation using TCGA and clinical cohorts

Abstract: Lymph node metastasis (LNM) is a major prognostic determinant in early-stage cervical squamous cell carcinoma (SCC); however, conventional preoperative imaging has…

Date: 2026-05-13