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Integrase inhibitor–based antiretroviral therapy drives gut microbiota remodeling and immune recovery in HIV infection

Abstract: The gastrointestinal tract serves as a major viral reservoir in HIV infection, and persistent gut dysbiosis contributes to systemic inflammation and immune dysfunction…

Date: 2026-05-12

Downregulation of PRPS2 inhibits tumor growth of non-small cell lung cancer by suppressing PI3K/AKT signaling

Abstract: This study aims to investigate the role of phosphoribosyl pyrophosphate synthetases 2 (PRPS2) in non-small cell lung cancer (NSCLC) and its underlying molecular…

Date: 2026-05-12

Multi-omics investigation of perineural invasion in head and neck squamous cell carcinoma: neuroimmune mechanisms and clinical implications

Abstract: Perineural invasion (PNI) is an aggressive feature in head and neck squamous cell carcinoma (HNSCC), but its molecular basis and neuroimmune implications, including…

Date: 2026-05-12

Learning curve of distal transradial access for coronary intervention: a single-center retrospective study

Abstract: The vascular access site for coronary intervention has evolved from the femoral artery to the conventional radial artery; more recently, the distal transradial access…

Date: 2026-05-12

Long-term clinical efficacy of Marshall vein ethanol infusion combined with catheter ablation for persistent AF

Abstract: Recurrent atrial arrhythmia after radiofrequency catheter ablation (RFCA) for persistent atrial fibrillation (AF) necessitates better strategies. Ethanol infusion of the…

Date: 2026-05-12

GLP-1 receptor agonists alleviate inflammatory responses and endothelial dysfunction in atherosclerosis by activating the Sema3A/NRP1 pathway

Abstract: This study aimed to investigate the mechanism by which GLP-1 RAs activate the Sema3A/NRP1 signaling pathway to alleviate inflammation and endothelial dysfunction in…

Date: 2026-05-12

Time to chemotherapy and oncofertility counseling in pediatric hematology/oncology patients: a single-center retrospective review

Abstract: The American Society of Reproductive Medicine and American Society of Clinical Oncology emphasize the importance of oncofertility counseling in pediatric cancer…

Date: 2026-05-11

Expression of ATRX, DAXX, PDX1, ARX, and somatostatin receptors in pancreatic neuroendocrine tumors: a clinicopathological study

Abstract: Recent studies have identified ATRX/DAXX and PDX1/ARX as biomarkers defining novel pancreatic neuroendocrine tumor (PanNET) subtypes, while the clinical significance of…

Date: 2026-05-11

Associations of FGF23 and Apelin-13 with osteoporosis and diabetic peripheral neuropathy in postmenopausal women with type 2 diabetes mellitus

Abstract: To investigate the correlations of various clinical indicators, fibroblast growth factor 23 (FGF23), and Apelin-13 with osteoporosis (OP) and diabetic peripheral…

Date: 2026-05-11

Clinical validation of an artificial intelligence model for thyroid fine-needle aspiration biopsy indication: comparison with TI-RADS systems and human specialists in a Chilean public hospital

Abstract: Ultrasound evaluation of thyroid nodules shows significant interobserver variability, contributing to the overutilization of fine-needle aspiration biopsy (FNA).…

Date: 2026-05-11