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Second-order regulation: IFN-? suppresses IL-17A-mediated type 3 inflammation

Abstract: T helper 1 (T H 1) cells often accompany T H 17 cells across diverse tissues in health and disease, including the lungs. However, roles for the T H 1 effector cytokine,…

Date: 2026-05-11

Cisplatin - induced peripheral neuropathy and biomarkers of gut microbial translocation in testicular germ cell tumor survivors

Abstract: Cisplatin-induced peripheral neuropathy (CIPN) is a frequent and often persistent complication in survivors of testicular germ cell tumors (GCT) treated with curative…

Date: 2026-05-11

Interpretable survival modeling integrating nutritional-inflammatory biomarkers in elderly patients with locally advanced esophageal squamous cell carcinoma treated with definitive radiotherapy

Abstract: Elderly patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving definitive radiotherapy show marked survival heterogeneity. As anatomical…

Date: 2026-05-11

Prognostic value of androgen receptor expression in ER-positive/HER2-negative breast cancer: evidence from a contemporary Chinese cohort

Abstract: The prognostic significance of androgen receptor (AR) expression in ER+/HER2? luminal breast cancer remains controversial, particularly in the context of neoadjuvant…

Date: 2026-05-11

Trends in the diagnosis of variant bladder cancer: a national retrospective cohort analysis

Abstract: The diagnosis of variant bladder cancer (VBC) has significant clinical implications, yet remains a challenge for pathologists and clinicians. Our objective was to…

Date: 2026-05-11

Development and validation of a pre-chemotherapy nomogram integrating systemic immune-inflammation index and prognostic nutritional index to predict severe adjuvant toxicity in colorectal cancer

Abstract: Severe toxicities frequently complicate adjuvant chemotherapy for stage II/III colorectal cancer (CRC), leading to dose reductions and compromised outcomes. While the…

Date: 2026-05-11

Spontaneous coronary artery dissection in an underrepresented region: insights from the Serbian (RS) SCAD registry

Abstract: Evidence on spontaneous coronary artery dissection (SCAD) is largely derived from Western registries, with limited data from Eastern transitional regions. The Serbian…

Date: 2026-05-11

Virtual patients and standardized patients combined training is associated with improved clinical reasoning among medical students

Abstract: To develop an artificial intelligence (AI)-driven virtual standardized patients (VSPs) system, and to evaluate its educational effectiveness when combined with…

Date: 2026-05-11

Artificial intelligence applied to post-resuscitation ECGs for early prognostication after out-of-hospital cardiac arrest

Abstract: There are limited tools for early outcome prediction after Out-of-Hospital Cardiac Arrest (OHCA). This study aimed to evaluate whether a machine learning model could…

Date: 2026-05-11

Implementation of third-generation digital PCR for non-invasive prenatal diagnosis of sickle cell disease and early detection. Pilot study

Abstract: Sickle cell disease (SCD) is one of the most prevalent autosomal recessive conditions worldwide, affecting more than 600,000 newborns annually. Despite advances in…

Date: 2026-05-08