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Therapeutic targets for diabetic nephropathy identified by druggable genome mendelian randomization: the role of the gut microbiota-metabolite axis

Abstract: Diabetic nephropathy (DN), a severe complication of diabetes, is influenced by genetic, immune, and gut microbial factors but lacks targeted therapeutic strategies.…

Date: 2026-05-08

Analysis of infection characteristics and clinical predictive indicators of different bacterial diabetic foot in Yunnan area

Abstract: To explore the infection characteristics of different bacterial diabetic foot (DF) in Yunnan area, and to provide reference basis and clinical predictive indicators for…

Date: 2026-05-08

A novel gain-of-function mutation (W818R) of calcium-sensing receptor in a family with autosomal dominant hypocalcemia type 1

Abstract: Autosomal dominant hypocalcemia type 1 (ADH1) is a rare inherited disorder caused by gain-of-function mutations in the calcium-sensing receptor ( CASR ) gene, with…

Date: 2026-05-08

Association analysis and exploratory mediation study of the stress-induced hyperglycaemia ratio and glycaemic ratio indices with diabetic retinopathy in patients with type 2 diabetes

Abstract: Diabetic retinopathy (DR) is a major microvascular complication of type 2 diabetes mellitus (T2DM), and traditional glycaemic control indicators struggle to…

Date: 2026-05-08

IgA nephropathy-associated breast milk B cell alterations

Abstract: IgA nephropathy (IgAN) is a mucosal immune-associated disease characterized by the overproduction of galactose-deficient IgA1 (Gd-IgA1) and formation of nephritogenic…

Date: 2026-05-08

Assessment of a risk warning model for depression in lymphedema patients after breast cancer surgery

Abstract: To identify independent risk factors for depression in breast cancer patients with postoperative lymphedema and develop an early warning model for depression prevention.…

Date: 2026-05-08

Clinical characteristics and factors associated with different BASP subtypes of androgenetic alopecia

Abstract: This study aimed to explore the associated factors for different basic and specific (BASP) classification subtypes of androgenic alopecia (AGA). This retrospective…

Date: 2026-05-08

Machine learning methods to predict leprosy misdiagnosis in Yunnan Province, People's Republic of China

Abstract: Leprosy is a chronic infectious disease caused by Mycobacterium leprae that is often misdiagnosed. This study aimed to identify factors associated with leprosy…

Date: 2026-05-08

Dissecting age-specific genetic architecture of vitiligo through integrative Post-GWAS analysis

Abstract: Vitiligo is a chronic acquired depigmentation disorder with a global prevalence of 0.5-2%. Early-onset (EO) and late-onset (LO) subtypes exhibit marked differences in…

Date: 2026-05-08

Diagnostic performance of wearable acoustic–electrocardiographic indices for screening secundum atrial septal defect in children

Abstract: To evaluate the diagnostic performance of acoustic–electrocardiographic indices derived from a wearable phonocardiogram–electrocardiogram (ECG) sensor for screening…

Date: 2026-05-08